Maternal dietary substrates and human fetal biophysical activity. I. The effects of tryptophan and glucose on fetal breathing movements

Lawrence D Devoe, Ramon A. Castillo, Nancy S. Searle, John R. Searle

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To study the effects of l-tryptophan and glucose on fetal breathing activity, we examined 40 women with normal term pregnancies, randomly assigned to four equal groups who either continued fasting (group C), received 1 gm of oral tryptophan (group T), received 100 gm of oral glucose (group G), or received both substrates (group T + G). Studies lasted 210 minutes, during which fetal breathing movements were observed with real-time ultrasonography and entered and analyzed for incidence, rate, and variability on a microcomputer. Plasma glucose and tryptophan levels were determined every 30 minutes. The incidence of fetal breathing movements declined in group C and rose significantly in the other groups. Breathing rates were unchanged in groups C and T but rose significantly in groups G and T + G during peak breathing intervals. Breath interval variability did not change significantly in any study group. Maternal administration of tryptophan is associated with an alteration in fetal breathing activity but to a lesser degree than that observed after maternal glucose loading.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume155
Issue number1
DOIs
StatePublished - Jan 1 1986

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Fetal Movement
Tryptophan
Respiration
Mothers
Glucose
Incidence
Microcomputers
Fasting
Ultrasonography
Pregnancy

Keywords

  • Tryptophan
  • fetal breathing movements
  • glucose

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Maternal dietary substrates and human fetal biophysical activity. I. The effects of tryptophan and glucose on fetal breathing movements. / Devoe, Lawrence D; Castillo, Ramon A.; Searle, Nancy S.; Searle, John R.

In: American Journal of Obstetrics and Gynecology, Vol. 155, No. 1, 01.01.1986, p. 135-139.

Research output: Contribution to journalArticle

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