@article{03e455283d514d289e8d17a44e05273e,
title = "Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study",
abstract = "Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen-DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.",
keywords = "dietary supplements, islet autoimmunity, omega-3 fatty acids, pregnancy, vitamin D",
author = "{The TEDDY study group} and Katherine Silvis and Aronsson, {Carin A.} and Xiang Liu and Ulla Uusitalo and Jimin Yang and Roy Tamura and {\AA}ke Lernmark and Marian Rewers and William Hagopian and She, {Jin Xiong} and Jin-Xiong She and Jorma Toppari and Anette Ziegler and Beena Akolkar and Jeffrey Krischer and Virtanen, {Suvi M.} and Norris, {Jill M.}",
note = "Funding Information: Juvenile Diabetes Research Foundation; NIH/ NCATS Clinical and Translational Science Award, Grant/Award Number: UL1 TR000064UL1 TR001082; University of Colorado; University of Florida; Centers for Disease Control and Prevention; Juvenile Diabetes Research Foundation; National Institute of Environmental Health Sciences; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: Contract No. HHSN267200700014CU01 Funding Information: We would like to thank all the children and their families who generously volunteered to participate in TEDDY. TEDDY Study was funded by U01 DK63829, U01 DK63861, U01 DK63821, U01 DK63865, U01 DK63863, U01 DK63836, U01 DK63790, UC4 DK63829, UC4 DK63861, UC4 DK63821, UC4 DK63865, UC4 DK63863, UC4 DK63836, UC4 DK95300, UC4 DK100238, UC4 DK106955, UC4 DK112243, UC4 DK117483, and Contract No. HHSN267200700014C from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, National Institute of Environmental Health Sciences, Juvenile Diabetes Research Foundation, and Centers for Disease Control and Prevention. This work was supported in part by the NIH/NCATS Clinical and Translational Science Awards to the University of Florida (UL1 TR000064) and the University of Colorado (UL1 TR001082). Funding Information: TEDDY is a prospective cohort study funded by the National Institutes of Health with the primary goal to identify environmental causes of T1D. It includes six clinical research centers—three in the United States: Colorado, Georgia/Florida, Washington and three in Europe: Finland, Germany, and Sweden. Detailed study design and methods have been previously published.16,17 The TEDDY study is conducted according to guidelines laid down by the Declaration of Helsinki, and all procedures involving human subjects were approved by local ethics boards or Institutional Review Boards. Written informed consents were obtained for all study participants from a parent or primary care-taker, separately, for genetic screening at birth and participation in prospective follow-up. Screening and follow-up are monitored by an External Advisory Board of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2019",
month = feb,
doi = "10.1111/pedi.12794",
language = "English (US)",
volume = "20",
pages = "86--92",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Blackwell Munksgaard",
number = "1",
}