Maternal smoking does not influence cord serum IgE or IgD concentrations

Dennis Randall Ownby, Christine Cole Johnson, Edward L. Peterson

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Increased cord blood IgE concentrations have been related to atopic risk in children, and a previous study reported increased cord blood IgE concentrations in smoking mothers. These associations suggest a relationship between maternal smoking during pregnancy and atopic risk. To evaluate this question, we prospectively studied parental smoking and cord blood IgE and IgD concentrations in a geographically defined group of women belonging to a health maintenance organization. Cord blood samples were obtained from 847 infants born to these women. Cotinine concentrations were measured in 114 cord blood samples to evaluate the veracity of the maternal smoking histories. Smoking during the prenatal period was reported by 144 mothers (17%) and 204 fathers (25%). Decreased birth weight and length were associated with maternal smoking (p < 0.001 for both), confirming previous studies. Neither maternal nor paternal smoking was found to be associated with IgE level in univariate or multivariate analyses. Maternal and paternal smoking was associated with IgD (p = 0.03 and p = 0.06, respectively) in univariate analysis. In multiple regression analysis controlling for potentially confounding variables, the association between paternal, but not maternal, smoking and IgD was sustained (p = 0.05 and p > 0.20, respectively). Our data do not demonstrate that maternal or paternal smoking increases cord blood IgE.

Original languageEnglish (US)
Pages (from-to)555-560
Number of pages6
JournalThe Journal of Allergy and Clinical Immunology
Volume88
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Immunoglobulin D
Immunoglobulin E
Fetal Blood
Smoking
Mothers
Serum
Cotinine
Health Maintenance Organizations
Birth Weight
Fathers
Pregnancy

Keywords

  • Cord serum
  • IgD
  • IgE
  • newborn infants
  • parental smoking

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Maternal smoking does not influence cord serum IgE or IgD concentrations. / Ownby, Dennis Randall; Johnson, Christine Cole; Peterson, Edward L.

In: The Journal of Allergy and Clinical Immunology, Vol. 88, No. 4, 01.01.1991, p. 555-560.

Research output: Contribution to journalArticle

Ownby, Dennis Randall ; Johnson, Christine Cole ; Peterson, Edward L. / Maternal smoking does not influence cord serum IgE or IgD concentrations. In: The Journal of Allergy and Clinical Immunology. 1991 ; Vol. 88, No. 4. pp. 555-560.
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