Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women

Jill A. Kanaley, Timothy D. Heden, Ying Liu, Lauren J. Sims, Adam T. Whaley-Connell, Anand Chockalingam, Kevin C Dellsperger

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women. Design and Methods: In a counterbalanced order, eight obese women completed two, 12-h conditions in which they consumed 1,500 calories (14% protein, 21% fat, and 65% carbohydrate) either as three 500 calorie liquid meals every 4-h or six 250 calorie liquid meals every 2-h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin. Results: The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dl 12 h) was significantly lower (P = 0.04) compared with the six meal condition (481 ± 155 mg/dl 12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/l.12 h) was significantly higher (P = 0.05) compared with the six meal condition (4,230 ± 757 pmol/l.12 h). Meal frequency had no influence on the other biochemical variables. Conclusions: Collectively, a three and six isocaloric high-carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalObesity
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Meals
Triglycerides
Insulin
Carbohydrates
LDL Cholesterol
Area Under Curve
Oxidative Stress
Antioxidants
Cholesterol
Aryldialkylphosphatase
Hyperlipidemias
HDL Cholesterol
Peroxidase
Fats
Proteins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Kanaley, J. A., Heden, T. D., Liu, Y., Sims, L. J., Whaley-Connell, A. T., Chockalingam, A., & Dellsperger, K. C. (2013). Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women. Obesity, 21(1), 123-129. https://doi.org/10.1038/oby.2012.171

Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women. / Kanaley, Jill A.; Heden, Timothy D.; Liu, Ying; Sims, Lauren J.; Whaley-Connell, Adam T.; Chockalingam, Anand; Dellsperger, Kevin C.

In: Obesity, Vol. 21, No. 1, 01.01.2013, p. 123-129.

Research output: Contribution to journalArticle

Kanaley, JA, Heden, TD, Liu, Y, Sims, LJ, Whaley-Connell, AT, Chockalingam, A & Dellsperger, KC 2013, 'Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women', Obesity, vol. 21, no. 1, pp. 123-129. https://doi.org/10.1038/oby.2012.171
Kanaley JA, Heden TD, Liu Y, Sims LJ, Whaley-Connell AT, Chockalingam A et al. Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women. Obesity. 2013 Jan 1;21(1):123-129. https://doi.org/10.1038/oby.2012.171
Kanaley, Jill A. ; Heden, Timothy D. ; Liu, Ying ; Sims, Lauren J. ; Whaley-Connell, Adam T. ; Chockalingam, Anand ; Dellsperger, Kevin C. / Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women. In: Obesity. 2013 ; Vol. 21, No. 1. pp. 123-129.
@article{c9df11f59e754b75a42ba09190727910,
title = "Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women",
abstract = "Objective: The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women. Design and Methods: In a counterbalanced order, eight obese women completed two, 12-h conditions in which they consumed 1,500 calories (14{\%} protein, 21{\%} fat, and 65{\%} carbohydrate) either as three 500 calorie liquid meals every 4-h or six 250 calorie liquid meals every 2-h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin. Results: The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dl 12 h) was significantly lower (P = 0.04) compared with the six meal condition (481 ± 155 mg/dl 12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/l.12 h) was significantly higher (P = 0.05) compared with the six meal condition (4,230 ± 757 pmol/l.12 h). Meal frequency had no influence on the other biochemical variables. Conclusions: Collectively, a three and six isocaloric high-carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.",
author = "Kanaley, {Jill A.} and Heden, {Timothy D.} and Ying Liu and Sims, {Lauren J.} and Whaley-Connell, {Adam T.} and Anand Chockalingam and Dellsperger, {Kevin C}",
year = "2013",
month = "1",
day = "1",
doi = "10.1038/oby.2012.171",
language = "English (US)",
volume = "21",
pages = "123--129",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Meal frequency differentially alters postprandial triacylglycerol and insulin concentrations in obese women

AU - Kanaley, Jill A.

AU - Heden, Timothy D.

AU - Liu, Ying

AU - Sims, Lauren J.

AU - Whaley-Connell, Adam T.

AU - Chockalingam, Anand

AU - Dellsperger, Kevin C

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective: The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women. Design and Methods: In a counterbalanced order, eight obese women completed two, 12-h conditions in which they consumed 1,500 calories (14% protein, 21% fat, and 65% carbohydrate) either as three 500 calorie liquid meals every 4-h or six 250 calorie liquid meals every 2-h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin. Results: The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dl 12 h) was significantly lower (P = 0.04) compared with the six meal condition (481 ± 155 mg/dl 12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/l.12 h) was significantly higher (P = 0.05) compared with the six meal condition (4,230 ± 757 pmol/l.12 h). Meal frequency had no influence on the other biochemical variables. Conclusions: Collectively, a three and six isocaloric high-carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.

AB - Objective: The aim of this study was to compare postprandial lipemia, oxidative stress, antioxidant activity, and insulinemia between a three and six isocaloric high-carbohydrate meal frequency pattern in obese women. Design and Methods: In a counterbalanced order, eight obese women completed two, 12-h conditions in which they consumed 1,500 calories (14% protein, 21% fat, and 65% carbohydrate) either as three 500 calorie liquid meals every 4-h or six 250 calorie liquid meals every 2-h. Blood samples were taken every 30 min and analyzed for triacylglycerol (TAG), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, oxidized low-density lipoprotein cholesterol, myeloperoxidase, paraoxonase-1 activity, and insulin. Results: The TAG incremental area under the curve (iAUC) during the three meal condition (321 ± 129 mg/dl 12 h) was significantly lower (P = 0.04) compared with the six meal condition (481 ± 155 mg/dl 12 h). The insulin iAUC during the three meal condition (5,549 ± 1,007 pmol/l.12 h) was significantly higher (P = 0.05) compared with the six meal condition (4,230 ± 757 pmol/l.12 h). Meal frequency had no influence on the other biochemical variables. Conclusions: Collectively, a three and six isocaloric high-carbohydrate meal frequency pattern differentially alters postprandial TAG and insulin concentrations but has no effect on postprandial cholesterol, oxidative stress, or antioxidant activity in obese women.

UR - http://www.scopus.com/inward/record.url?scp=84876294450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876294450&partnerID=8YFLogxK

U2 - 10.1038/oby.2012.171

DO - 10.1038/oby.2012.171

M3 - Article

VL - 21

SP - 123

EP - 129

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 1

ER -