Measurement of rat brain tumor kinetics using an intravascular MR contrast agent and DCE-MRI nested model selection

Wilson B. Chwang, Rajan Jain, Hassan Bagher-Ebadian, Siamak P. Nejad-Davarani, A. S.M. Iskander, Ashley VanSlooten, Lonni Schultz, Ali Syed Arbab, James R. Ewing

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Purpose: Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a rat glioma model, and nested model selection (NMS), to compare estimates of the pharmacokinetic parameters vp, Ktrans, and ve for two different contrast agents (CAs)gadofosveset, which reversibly binds to human serum albumin, and gadopentetate dimeglumine, which does not.

Materials and Methods: DCE-MRI studies were performed on nine Fisher 344 rats inoculated intracerebrally with 9L gliosarcoma cells using both gadofosveset and gadopentetate. The parameters vp, Ktrans, and ve were estimated using NMS.

Results: Ktrans estimates using gadofosveset, compared to gadopentetate, differed in their means (gadofosveset 0.025 ± 0.008 min-1 vs. gadopentetate 0.046 ± 0.011 min-1; P = 0.0039). This difference notwithstanding, the intraclass correlation coefficient (ICC) for the two estimates of Ktrans showed nearly perfect linear dependence (ICC = 0.8479 by Pearson's r). Other estimates, ve (gadofosveset 22.7 ± 4.7% vs. gadopentetate 23.6 ± 5.6%; P = 0.4258) and vp (gadofosveset 1.5 ± 0.5% vs. gadopentetate 1.6 ± 0.4%; P = 0.25), were not different in their means between the two CAs, and there was almost perfect agreement for ve (ICC = 0.8798) and substantial agreement for vp (ICC = 0.7981) between the two CAs.

Conclusion: Estimates of Ktrans were statistically different using gadofosveset and gadopentetate, whereas ve and vp were similar with two CAs. NMS produced robust estimates of pharmacokinetic parameters using DCE-MRI that show promise as important measures of tumor physiology and microenvironment.

Original languageEnglish (US)
Pages (from-to)1223-1229
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - Nov 1 2014


  • Contrast agent
  • Gadofosveset
  • Gadopentetate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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