Mechanical cardiac assistance improves outcome after prolonged hemorrhagic shock

Branislav Radovancevic, Murat Sargin, Egemen Tuzun, Dong Liu, Vijaykumar Surendrakant Patel, Gil Costas, Denise Byler, Dan Tamez, O. H. Frazier

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To examine the use of mechanical cardiac assist devices in prolonged hemorrhagic shock lasting up to 120 min. We induced hemorrhagic shock in anesthetized calves that were then treated 30 or 120 min later with either conventional fluid and blood resuscitation methods or the implantation of a mechanical assist device in addition to conventional fluid resuscitation. We measured hemodynamic and hematologic variables, inflammatory mediators, endorgan function via biochemical parameters, and survival time. Although cardiac output and blood flow in the left anterior descending artery decreased significantly in all calves at the end of the hemorrhage period, the drop was significantly less severe in calves who received mechanical assistance in addition to fluids. Furthermore, the biochemical profile, indicating liver and kidney function, and survival time were better after hemorrhage in device-treated calves than in conventionally treated calves. Levels of inflammatory mediators, which contribute to cell and organ dysfunction, were increased after hemorrhage, but calves with mechanical devices had less of an increase than did calves treated only with fluids. Our results indicate that the use of a mechanical cardiac assist device in combination with conventional fluid and blood resuscitation methods improves survival and end-organ recovery and decreases the myocardial inflammatory response after prolonged hemorrhagic shock when compared with the sole use of conventional fluid resuscitation techniques.

Original languageEnglish (US)
Pages (from-to)675-679
Number of pages5
JournalShock
Volume30
Issue number6
DOIs
StatePublished - Dec 1 2008

Fingerprint

Hemorrhagic Shock
Resuscitation
Equipment and Supplies
Hemorrhage
Tissue Survival
Cardiac Output
Arteries
Hemodynamics
Kidney
Liver

Keywords

  • Heart-assist devices
  • Hemorrhagic
  • Shock
  • Systemic inflamatory response syndrome

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Radovancevic, B., Sargin, M., Tuzun, E., Liu, D., Patel, V. S., Costas, G., ... Frazier, O. H. (2008). Mechanical cardiac assistance improves outcome after prolonged hemorrhagic shock. Shock, 30(6), 675-679. https://doi.org/10.1097/SHK.0b013e31816f22bf

Mechanical cardiac assistance improves outcome after prolonged hemorrhagic shock. / Radovancevic, Branislav; Sargin, Murat; Tuzun, Egemen; Liu, Dong; Patel, Vijaykumar Surendrakant; Costas, Gil; Byler, Denise; Tamez, Dan; Frazier, O. H.

In: Shock, Vol. 30, No. 6, 01.12.2008, p. 675-679.

Research output: Contribution to journalArticle

Radovancevic, B, Sargin, M, Tuzun, E, Liu, D, Patel, VS, Costas, G, Byler, D, Tamez, D & Frazier, OH 2008, 'Mechanical cardiac assistance improves outcome after prolonged hemorrhagic shock', Shock, vol. 30, no. 6, pp. 675-679. https://doi.org/10.1097/SHK.0b013e31816f22bf
Radovancevic, Branislav ; Sargin, Murat ; Tuzun, Egemen ; Liu, Dong ; Patel, Vijaykumar Surendrakant ; Costas, Gil ; Byler, Denise ; Tamez, Dan ; Frazier, O. H. / Mechanical cardiac assistance improves outcome after prolonged hemorrhagic shock. In: Shock. 2008 ; Vol. 30, No. 6. pp. 675-679.
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