Mediator1: An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Abstract

Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathways importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
JournalJournal of Investigative Dermatology
Volume132
Issue number4
DOIs
StatePublished - Jan 1 2012

Fingerprint

Calcitriol Receptors
Hair Follicle
Skin
Artificial Skin
Rickets
Calcitriol
Keratinocytes
Hair
Transgenic Mice
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Mediator1 : An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology. / Bollag, Wendy B.

In: Journal of Investigative Dermatology, Vol. 132, No. 4, 01.01.2012, p. 1068-1070.

Research output: Contribution to journalComment/debate

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