Mediator1: An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology

Wendy B. Bollag

doi:10.1038/jid.2012.25

Mediator1: An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology

Wendy B. Bollag

Physiology

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathways importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.

Original language	English (US)
Pages (from-to)	1068-1070
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	132
Issue number	4
DOIs	https://doi.org/10.1038/jid.2012.25
State	Published - Apr 2012

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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title = "Mediator1: An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology",

abstract = "Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathways importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.",

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