Abstract
Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathways importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1068-1070 |
| Number of pages | 3 |
| Journal | Journal of Investigative Dermatology |
| Volume | 132 |
| Issue number | 4 |
| DOIs |
|
| State | Published - Apr 2012 |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Mediator1 : An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology. / Bollag, Wendy B.
In: Journal of Investigative Dermatology, Vol. 132, No. 4, 04.2012, p. 1068-1070.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Mediator1
T2 - An important intermediary of vitamin D receptor-regulated epidermal function and hair follicle biology
AU - Bollag, Wendy B.
PY - 2012/4
Y1 - 2012/4
N2 - Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathways importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.
AB - Considerable data in the literature support the idea that 1,25-dihydroxyvitamin D3 and the vitamin D receptor (VDR) are involved in regulating skin biology. Studies using cultured keratinocytes, artificial human skin, and transgenic mouse models, as well as observations in patients with rickets, provide evidence of this pathways importance in epidermal proliferation and differentiation and the hair growth cycle. The report by Oda et al. in this issue also indicates an important role of the VDR coactivator mediator 1 in these processes.
UR - http://www.scopus.com/inward/record.url?scp=84858173637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858173637&partnerID=8YFLogxK
U2 - 10.1038/jid.2012.25
DO - 10.1038/jid.2012.25
M3 - Comment/debate
C2 - 22418940
AN - SCOPUS:84858173637
VL - 132
SP - 1068
EP - 1070
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 4
ER -