Medical countermeasures for radiation combined injury: Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007

Andrea L. DiCarlo, Richard J. Hatchett, Joseph Michael Kaminski, G. David Ledney, Terry C. Pellmar, Paul Okunieff, Narayani Ramakrishnan

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Non-clinical human radiation exposure events such as the Hiroshima and Nagasaki bombings or the Chernobyl accident are often coupled with other forms of injury, such as wounds, burns, blunt trauma, and infection. Radiation combined injury would also be expected after a radiological or nuclear attack. Few animal models of radiation combined injury exist, and mechanisms underlying the high mortality associated with complex radiation injuries are poorly understood. Medical countermeasures are currently available for management of the non-radiation components of radiation combined injury, but it is not known whether treatments for other insults will be effective when the injury is combined with radiation exposure. Further research is needed to elucidate mechanisms behind the synergistic lethality of radiation combined injury and to identify targets for medical countermeasures. To address these issues, the National Institute of Allergy and Infectious Diseases convened a workshop to make recommendations on the development of animal models of radiation combined injury, possible mechanisms of radiation combined injury, and future directions for countermeasure research, including target identification and end points to evaluate treatment efficacy.

Original languageEnglish (US)
Pages (from-to)712-721
Number of pages10
JournalRadiation Research
Volume169
Issue number6
DOIs
StatePublished - Jun 1 2008

Fingerprint

National Institute of Allergy and Infectious Diseases (U.S.)
radiation injuries
Radiation Injuries
countermeasures
blasts
Sepsis
Radiation
Education
Wounds and Injuries
radiation
animal models
radiation dosage
infectious diseases
Animal Models
lethality
mortality
Burns
Research
Accidents
accidents

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

DiCarlo, A. L., Hatchett, R. J., Kaminski, J. M., Ledney, G. D., Pellmar, T. C., Okunieff, P., & Ramakrishnan, N. (2008). Medical countermeasures for radiation combined injury: Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007. Radiation Research, 169(6), 712-721. https://doi.org/10.1667/RR1295.1

Medical countermeasures for radiation combined injury : Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007. / DiCarlo, Andrea L.; Hatchett, Richard J.; Kaminski, Joseph Michael; Ledney, G. David; Pellmar, Terry C.; Okunieff, Paul; Ramakrishnan, Narayani.

In: Radiation Research, Vol. 169, No. 6, 01.06.2008, p. 712-721.

Research output: Contribution to journalArticle

DiCarlo, AL, Hatchett, RJ, Kaminski, JM, Ledney, GD, Pellmar, TC, Okunieff, P & Ramakrishnan, N 2008, 'Medical countermeasures for radiation combined injury: Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007', Radiation Research, vol. 169, no. 6, pp. 712-721. https://doi.org/10.1667/RR1295.1
DiCarlo, Andrea L. ; Hatchett, Richard J. ; Kaminski, Joseph Michael ; Ledney, G. David ; Pellmar, Terry C. ; Okunieff, Paul ; Ramakrishnan, Narayani. / Medical countermeasures for radiation combined injury : Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007. In: Radiation Research. 2008 ; Vol. 169, No. 6. pp. 712-721.
@article{f730872e77a545beaa3a98991727314f,
title = "Medical countermeasures for radiation combined injury: Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007",
abstract = "Non-clinical human radiation exposure events such as the Hiroshima and Nagasaki bombings or the Chernobyl accident are often coupled with other forms of injury, such as wounds, burns, blunt trauma, and infection. Radiation combined injury would also be expected after a radiological or nuclear attack. Few animal models of radiation combined injury exist, and mechanisms underlying the high mortality associated with complex radiation injuries are poorly understood. Medical countermeasures are currently available for management of the non-radiation components of radiation combined injury, but it is not known whether treatments for other insults will be effective when the injury is combined with radiation exposure. Further research is needed to elucidate mechanisms behind the synergistic lethality of radiation combined injury and to identify targets for medical countermeasures. To address these issues, the National Institute of Allergy and Infectious Diseases convened a workshop to make recommendations on the development of animal models of radiation combined injury, possible mechanisms of radiation combined injury, and future directions for countermeasure research, including target identification and end points to evaluate treatment efficacy.",
author = "DiCarlo, {Andrea L.} and Hatchett, {Richard J.} and Kaminski, {Joseph Michael} and Ledney, {G. David} and Pellmar, {Terry C.} and Paul Okunieff and Narayani Ramakrishnan",
year = "2008",
month = "6",
day = "1",
doi = "10.1667/RR1295.1",
language = "English (US)",
volume = "169",
pages = "712--721",
journal = "Radiation Research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "6",

}

TY - JOUR

T1 - Medical countermeasures for radiation combined injury

T2 - Radiation with burn, blast, trauma and/or sepsis. Report of an NIAID Workshop, March 26-27, 2007

AU - DiCarlo, Andrea L.

AU - Hatchett, Richard J.

AU - Kaminski, Joseph Michael

AU - Ledney, G. David

AU - Pellmar, Terry C.

AU - Okunieff, Paul

AU - Ramakrishnan, Narayani

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Non-clinical human radiation exposure events such as the Hiroshima and Nagasaki bombings or the Chernobyl accident are often coupled with other forms of injury, such as wounds, burns, blunt trauma, and infection. Radiation combined injury would also be expected after a radiological or nuclear attack. Few animal models of radiation combined injury exist, and mechanisms underlying the high mortality associated with complex radiation injuries are poorly understood. Medical countermeasures are currently available for management of the non-radiation components of radiation combined injury, but it is not known whether treatments for other insults will be effective when the injury is combined with radiation exposure. Further research is needed to elucidate mechanisms behind the synergistic lethality of radiation combined injury and to identify targets for medical countermeasures. To address these issues, the National Institute of Allergy and Infectious Diseases convened a workshop to make recommendations on the development of animal models of radiation combined injury, possible mechanisms of radiation combined injury, and future directions for countermeasure research, including target identification and end points to evaluate treatment efficacy.

AB - Non-clinical human radiation exposure events such as the Hiroshima and Nagasaki bombings or the Chernobyl accident are often coupled with other forms of injury, such as wounds, burns, blunt trauma, and infection. Radiation combined injury would also be expected after a radiological or nuclear attack. Few animal models of radiation combined injury exist, and mechanisms underlying the high mortality associated with complex radiation injuries are poorly understood. Medical countermeasures are currently available for management of the non-radiation components of radiation combined injury, but it is not known whether treatments for other insults will be effective when the injury is combined with radiation exposure. Further research is needed to elucidate mechanisms behind the synergistic lethality of radiation combined injury and to identify targets for medical countermeasures. To address these issues, the National Institute of Allergy and Infectious Diseases convened a workshop to make recommendations on the development of animal models of radiation combined injury, possible mechanisms of radiation combined injury, and future directions for countermeasure research, including target identification and end points to evaluate treatment efficacy.

UR - http://www.scopus.com/inward/record.url?scp=44849121666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44849121666&partnerID=8YFLogxK

U2 - 10.1667/RR1295.1

DO - 10.1667/RR1295.1

M3 - Article

C2 - 18494548

AN - SCOPUS:44849121666

VL - 169

SP - 712

EP - 721

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

IS - 6

ER -