Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern, Sandra A. Carson, Huiman X. Barnhart, Evan R. Myers, Richard S. Legro, Michael P. Diamond, Bruce R. Carr, William D. Schlaff, Christos Coutifaris, Nicholas A. Cataldo, Michael P. Steinkampf, John E. Nestler, Gabey Gosman, Phyllis C. Leppert, Linda C. Giudice

Research output: Contribution to journalArticle

7 Scopus citations


We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

Original languageEnglish (US)
Pages (from-to)1283-1286
Number of pages4
JournalFertility and sterility
Issue number4
Publication statusPublished - Oct 1 2008
Externally publishedYes


ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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