Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern, Sandra A. Carson, Huiman X. Barnhart, Evan R. Myers, Richard S. Legro, Michael Peter Diamond, Bruce R. Carr, William D. Schlaff, Christos Coutifaris, Nicholas A. Cataldo, Michael P. Steinkampf, John E. Nestler, Gabey Gosman, Phyllis C. Leppert, Linda C. Giudice

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

Original languageEnglish (US)
Pages (from-to)1283-1286
Number of pages4
JournalFertility and sterility
Volume90
Issue number4
DOIs
StatePublished - Oct 1 2008

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National Institute of Child Health and Human Development (U.S.)
Reproductive Medicine
Medication Adherence
Polycystic Ovary Syndrome
Metformin
Pregnancy
Ovulation
Tablets
Clomiphene
Pregnancy Rate
Therapeutics
Physicians

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. / McGovern, Peter G.; Carson, Sandra A.; Barnhart, Huiman X.; Myers, Evan R.; Legro, Richard S.; Diamond, Michael Peter; Carr, Bruce R.; Schlaff, William D.; Coutifaris, Christos; Cataldo, Nicholas A.; Steinkampf, Michael P.; Nestler, John E.; Gosman, Gabey; Leppert, Phyllis C.; Giudice, Linda C.

In: Fertility and sterility, Vol. 90, No. 4, 01.10.2008, p. 1283-1286.

Research output: Contribution to journalArticle

McGovern, PG, Carson, SA, Barnhart, HX, Myers, ER, Legro, RS, Diamond, MP, Carr, BR, Schlaff, WD, Coutifaris, C, Cataldo, NA, Steinkampf, MP, Nestler, JE, Gosman, G, Leppert, PC & Giudice, LC 2008, 'Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial', Fertility and sterility, vol. 90, no. 4, pp. 1283-1286. https://doi.org/10.1016/j.fertnstert.2007.09.004
McGovern, Peter G. ; Carson, Sandra A. ; Barnhart, Huiman X. ; Myers, Evan R. ; Legro, Richard S. ; Diamond, Michael Peter ; Carr, Bruce R. ; Schlaff, William D. ; Coutifaris, Christos ; Cataldo, Nicholas A. ; Steinkampf, Michael P. ; Nestler, John E. ; Gosman, Gabey ; Leppert, Phyllis C. ; Giudice, Linda C. / Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. In: Fertility and sterility. 2008 ; Vol. 90, No. 4. pp. 1283-1286.
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