Meta-analysis of cytokines and chemokines in suicidality

Distinguishing suicidal versus nonsuicidal patients

Carmen Black, Brian J Miller

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

BACKGROUND: Major psychiatric disorders are associated with inflammation. Aberrant cytokine and chemokine levels have been associated with psychiatric disorders and suicidal behavior. We performed a meta-analysis of cytokine and chemokine levels in patients with versus without suicidality and patients with suicidality versus healthy controls. METHODS: We identified articles by searching MEDLINE, PsycINFO, and Thomson Reuters Web of Knowledge databases and the reference lists of identified studies. RESULTS: Study inclusion criteria were met by 18 studies comprising 583 patients with suicidality, 315 patients without suicidality, and 845 healthy control subjects. Levels of interleukin (IL)-1β and IL-6 were significantly increased in blood and postmortem brain samples of patients with suicidality compared with both patients without suicidality and healthy control subjects (p <.05 for each). In vitro IL-2 production by peripheral blood mononuclear cells was significantly decreased in patients with suicidality compared with both patients without suicidality and healthy controls (p <.01 for each). Cerebrospinal fluid levels of IL-8 were significantly decreased in patients with suicidality versus control subjects (p,.05). CONCLUSIONS: We found evidence for aberrant cytokine levels in blood, cerebrospinal fluid, and postmortem brain samples of patients with suicidality. Levels of IL-1β and IL-6 were most robustly associated with suicidality, and these cytokines may help distinguish suicidal from nonsuicidal patients. Rigorously designed longitudinal studies are needed to evaluate these associations further.

Original languageEnglish (US)
Pages (from-to)28-37
Number of pages10
JournalBiological Psychiatry
Volume78
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Chemokines
Meta-Analysis
Cytokines
Interleukin-1
Psychiatry
Cerebrospinal Fluid
Interleukin-6
Healthy Volunteers
Brain
Interleukin-8
MEDLINE
Interleukin-2
Longitudinal Studies
Blood Cells
Databases
Inflammation

Keywords

  • Chemokines
  • Cytokines
  • Depression
  • Inflammation
  • Meta-analysis
  • Suicide

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Meta-analysis of cytokines and chemokines in suicidality : Distinguishing suicidal versus nonsuicidal patients. / Black, Carmen; Miller, Brian J.

In: Biological Psychiatry, Vol. 78, No. 1, 01.01.2015, p. 28-37.

Research output: Contribution to journalArticle

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