Meta-prediction of MTHFR gene polymorphism and air pollution on the risks of congenital heart defects worldwide

A transgenerational analysis

Hsiao Ling Yang, Ya Ling Yang, Chong Ho Yu, Shyang-Yun Pamela Shiao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Congenital heart disease (CHD) is the leading cause of death in children, and is affected by genetic and environmental factors. To investigate the association of air pollution with methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and the risk of CHD, we included 58 study groups of children and parents, with 12,347 cases and 18,106 controls worldwide. Both MTHFR C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents. Countries with greater risks of CHD with a pooled risk ratio (RR) > 2 from MTHFR 677 polymorphisms included Germany, Portugal, China, and Egypt for children; and Brazil, Puerto Rico, Mexico, China, and Egypt for mothers. Whereas, countries with greater risk of CHD with RR > 2 from MTHFR 1298 polymorphisms included Taiwan, Turkey, and Egypt for children; and Brazil, China, and Egypt for mothers. Additionally, meta-prediction analysis revealed that the percentages of MTHFR 677TT and TT plus CT polymorphisms together were increased in countries with higher levels of air pollution, with a trend of increased CHD risks with higher levels of air pollution for children (p = 0.07). Our findings may have significant implications for inflammatory pathways in association with MTHFR polymorphisms and future intervention studies to correct for folate-related enzyme deficits resultied from MTHFR polymorphisms to prevent CHDs for future generations.

Original languageEnglish (US)
Article number1660
JournalInternational journal of environmental research and public health
Volume15
Issue number8
DOIs
StatePublished - Aug 5 2018

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Methylenetetrahydrofolate Reductase (NADPH2)
Congenital Heart Defects
Air Pollution
Heart Diseases
Egypt
Genes
China
Brazil
Parents
Odds Ratio
Mothers
Puerto Rico
Portugal
Social Responsibility
Turkey
Mexico
Taiwan
Folic Acid
Germany
Meta-Analysis

Keywords

  • Air pollution
  • Congenital
  • Heart defect
  • Meta-predictive analysis
  • Methylenetetrahydrofolate reductase
  • Polymorphism

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Meta-prediction of MTHFR gene polymorphism and air pollution on the risks of congenital heart defects worldwide : A transgenerational analysis. / Yang, Hsiao Ling; Yang, Ya Ling; Yu, Chong Ho; Shiao, Shyang-Yun Pamela.

In: International journal of environmental research and public health, Vol. 15, No. 8, 1660, 05.08.2018.

Research output: Contribution to journalArticle

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