Metabolic changes following eccentric exercise in trained and untrained men

W. J. Evans, C. N. Meredith, J. G. Cannon, C. A. Dinarello, W. R. Frontera, V. A. Hughes, B. H. Jones, H. G. Knuttgen

Research output: Contribution to journalArticle

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Abstract

The efects of one 45-min bout of high-intensity eccentric exercise (250 W) were studied in four male runners and five untrained men. Plasma creatine kinase (CK) activity in these runners was higher (P < 0.001) than in the untrained men before exercise and peaked at 207 IU/ml 1 day after exercise, whereas in untrained men the maximum was 2,143 IU/ml 5 days after exercise. Plasma interleukin-1 (IL-1) in the trained men was also higher (P < 0.001) than in the untrained men before exercise but did not significantly increase after exercise. In the untrained men, IL-1 was significantly elevated 3 h after exercise (P < 0.001). In the untrained group only, 24-h urines were collected before and after exercise while the men consumed a meat-free diet. Urinary 3-methylhistidine/creatinine in the untrained group rose significantly from 127 μmol/g before exercise to 180 μmol/g 10 days after exercise. The results suggest that in untrained men eccentric execise leads to a metabolic response indicative of delayed muscle damage. Regularly performed long distance running was associated with chronically elevated plasma IL-1 levels and serum CK activities with acute increases after an eccentric exercise bout.

Original languageEnglish (US)
Pages (from-to)1864-1868
Number of pages5
JournalJournal of Applied Physiology
Volume61
Issue number5
StatePublished - Dec 1 1986

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Exercise
Interleukin-1
Creatine Kinase
Running
Meat
Creatinine
Urine
Diet
Muscles
Serum

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Evans, W. J., Meredith, C. N., Cannon, J. G., Dinarello, C. A., Frontera, W. R., Hughes, V. A., ... Knuttgen, H. G. (1986). Metabolic changes following eccentric exercise in trained and untrained men. Journal of Applied Physiology, 61(5), 1864-1868.

Metabolic changes following eccentric exercise in trained and untrained men. / Evans, W. J.; Meredith, C. N.; Cannon, J. G.; Dinarello, C. A.; Frontera, W. R.; Hughes, V. A.; Jones, B. H.; Knuttgen, H. G.

In: Journal of Applied Physiology, Vol. 61, No. 5, 01.12.1986, p. 1864-1868.

Research output: Contribution to journalArticle

Evans, WJ, Meredith, CN, Cannon, JG, Dinarello, CA, Frontera, WR, Hughes, VA, Jones, BH & Knuttgen, HG 1986, 'Metabolic changes following eccentric exercise in trained and untrained men', Journal of Applied Physiology, vol. 61, no. 5, pp. 1864-1868.
Evans WJ, Meredith CN, Cannon JG, Dinarello CA, Frontera WR, Hughes VA et al. Metabolic changes following eccentric exercise in trained and untrained men. Journal of Applied Physiology. 1986 Dec 1;61(5):1864-1868.
Evans, W. J. ; Meredith, C. N. ; Cannon, J. G. ; Dinarello, C. A. ; Frontera, W. R. ; Hughes, V. A. ; Jones, B. H. ; Knuttgen, H. G. / Metabolic changes following eccentric exercise in trained and untrained men. In: Journal of Applied Physiology. 1986 ; Vol. 61, No. 5. pp. 1864-1868.
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