Metabolic effects of isoflurane on rat lungs perfused in situ

Dan C Martin, Anne M. Carr, Clyde A. Watkins

Research output: Contribution to journalArticle

Abstract

1. The current experiments studied the effects of the inhalation anesthetic, isoflurane, on 5-hydroxytryptamine (5-HT) metabolism, protein synthesis, and angiotensin-converting enzyme activity in perfused rat lungs. 2. Under first order reaction conditions, isoflurane decreased the accumulation of tissue 5-hydroxyindoleacetic acid, the principle metabolite of 5-HT in a concentration-related, competitive, and reversible manner, indicating inhibition of endothelial 5-HT uptake. 3. In apparent contrast, isoflurane appeared to stimulate uptake of 5-HT by an imipramine-sensitive process, into a cell type unable to metabolize the parent amine. 4. Isoflurane increased absolute angiotensin-converting enzyme activity only at an inspired concentration of 5%. The anesthetic did not affect lung protein synthesis.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalGeneral Pharmacology
Volume21
Issue number4
DOIs
StatePublished - Jan 1 1990

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Isoflurane
Serotonin
Lung
Peptidyl-Dipeptidase A
Inhalation Anesthetics
Hydroxyindoleacetic Acid
Imipramine
Amines
Anesthetics
Proteins

ASJC Scopus subject areas

  • Pharmacology

Cite this

Metabolic effects of isoflurane on rat lungs perfused in situ. / Martin, Dan C; Carr, Anne M.; Watkins, Clyde A.

In: General Pharmacology, Vol. 21, No. 4, 01.01.1990, p. 477-481.

Research output: Contribution to journalArticle

Martin, Dan C ; Carr, Anne M. ; Watkins, Clyde A. / Metabolic effects of isoflurane on rat lungs perfused in situ. In: General Pharmacology. 1990 ; Vol. 21, No. 4. pp. 477-481.
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