Metal exposures in an inner-city neonatal population

Elizabeth A. Jones, J. Michael Wright, Glenn Rice, Brian T. Buckley, Melina S. Magsumbol, Dana B. Barr, Bryan L. Williams

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Objectives: We measured concentrations of lead (Pb), manganese (Mn), chromium (Cr), and copper (Cu) in umbilical cord whole blood and examined sources of environmental Pb exposures in a predominantly African-American population. Methods: Between April and July 2006, we collected reproductive histories, questionnaires, and blood samples from 102 women, aged 16-45. years, who delivered at a Memphis, TN hospital. Results: The prevalence of preeclampsia and low birth weight infancy in the study population was 11% and 10%, respectively. Twenty-eight percent of mothers reported living near a potential Pb-contaminated area, while 43% lived in a residence built before 1978. Geometric mean (GM) concentrations for umbilical cord blood in the study population were 1.3, 3.5, 9.0, and 52.0μg/dL for Pb, Mn, Cr, and Cu, respectively. Six neonates had cord blood Pb (CBL) concentrations above 10μg/dL, while 20 had CBL concentrations ≥ 2μg/dL. GM umbilical CBL levels were higher in neonates born to women living near a potential Pb-contaminated area (2.2 vs. 1.1μg/dL) and those with friends, family or household members exposed to lead products (1.6 vs. 1.1μg/dL). Some evidence of an exposure-response relationship was also detected between all four metal concentrations and an increasing number of maternal lead exposures. After adjustment for confounding, proximity to a Pb-contaminated area was the strongest environmental determinant of CBL levels among neonates with CBL concentrations of ≥ 2μg/dL (odds ratio. =5.1; 95% CI. =1.6, 16.7). Conclusions: Metal concentrations were elevated in this population, and CBL levels were associated with proximity to Pb-contaminated areas.

Original languageEnglish (US)
Pages (from-to)649-654
Number of pages6
JournalEnvironment International
Volume36
Issue number7
DOIs
StatePublished - Oct 2010
Externally publishedYes

Keywords

  • Environmental epidemiology
  • Lead
  • Metals
  • Pregnancy
  • Urban health

ASJC Scopus subject areas

  • Environmental Science(all)

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    Jones, E. A., Wright, J. M., Rice, G., Buckley, B. T., Magsumbol, M. S., Barr, D. B., & Williams, B. L. (2010). Metal exposures in an inner-city neonatal population. Environment International, 36(7), 649-654. https://doi.org/10.1016/j.envint.2010.04.007