Metal exposures in an inner-city neonatal population

Elizabeth A. Jones, J. Michael Wright, Glenn Rice, Brian T. Buckley, Melina S. Magsumbol, Dana B. Barr, Bryan L Williams

Research output: Contribution to journalArticle

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Abstract

Objectives: We measured concentrations of lead (Pb), manganese (Mn), chromium (Cr), and copper (Cu) in umbilical cord whole blood and examined sources of environmental Pb exposures in a predominantly African-American population. Methods: Between April and July 2006, we collected reproductive histories, questionnaires, and blood samples from 102 women, aged 16-45. years, who delivered at a Memphis, TN hospital. Results: The prevalence of preeclampsia and low birth weight infancy in the study population was 11% and 10%, respectively. Twenty-eight percent of mothers reported living near a potential Pb-contaminated area, while 43% lived in a residence built before 1978. Geometric mean (GM) concentrations for umbilical cord blood in the study population were 1.3, 3.5, 9.0, and 52.0μg/dL for Pb, Mn, Cr, and Cu, respectively. Six neonates had cord blood Pb (CBL) concentrations above 10μg/dL, while 20 had CBL concentrations ≥ 2μg/dL. GM umbilical CBL levels were higher in neonates born to women living near a potential Pb-contaminated area (2.2 vs. 1.1μg/dL) and those with friends, family or household members exposed to lead products (1.6 vs. 1.1μg/dL). Some evidence of an exposure-response relationship was also detected between all four metal concentrations and an increasing number of maternal lead exposures. After adjustment for confounding, proximity to a Pb-contaminated area was the strongest environmental determinant of CBL levels among neonates with CBL concentrations of ≥ 2μg/dL (odds ratio. =5.1; 95% CI. =1.6, 16.7). Conclusions: Metal concentrations were elevated in this population, and CBL levels were associated with proximity to Pb-contaminated areas.

Original languageEnglish (US)
Pages (from-to)649-654
Number of pages6
JournalEnvironment International
Volume36
Issue number7
DOIs
StatePublished - Jan 1 2010

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blood
metal
neonate
chromium
manganese
exposure
inner city
African American
copper
contaminated area
history

Keywords

  • Environmental epidemiology
  • Lead
  • Metals
  • Pregnancy
  • Urban health

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Jones, E. A., Wright, J. M., Rice, G., Buckley, B. T., Magsumbol, M. S., Barr, D. B., & Williams, B. L. (2010). Metal exposures in an inner-city neonatal population. Environment International, 36(7), 649-654. https://doi.org/10.1016/j.envint.2010.04.007

Metal exposures in an inner-city neonatal population. / Jones, Elizabeth A.; Wright, J. Michael; Rice, Glenn; Buckley, Brian T.; Magsumbol, Melina S.; Barr, Dana B.; Williams, Bryan L.

In: Environment International, Vol. 36, No. 7, 01.01.2010, p. 649-654.

Research output: Contribution to journalArticle

Jones, EA, Wright, JM, Rice, G, Buckley, BT, Magsumbol, MS, Barr, DB & Williams, BL 2010, 'Metal exposures in an inner-city neonatal population', Environment International, vol. 36, no. 7, pp. 649-654. https://doi.org/10.1016/j.envint.2010.04.007
Jones EA, Wright JM, Rice G, Buckley BT, Magsumbol MS, Barr DB et al. Metal exposures in an inner-city neonatal population. Environment International. 2010 Jan 1;36(7):649-654. https://doi.org/10.1016/j.envint.2010.04.007
Jones, Elizabeth A. ; Wright, J. Michael ; Rice, Glenn ; Buckley, Brian T. ; Magsumbol, Melina S. ; Barr, Dana B. ; Williams, Bryan L. / Metal exposures in an inner-city neonatal population. In: Environment International. 2010 ; Vol. 36, No. 7. pp. 649-654.
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AU - Rice, Glenn

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AU - Barr, Dana B.

AU - Williams, Bryan L

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KW - Metals

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