Metastatic hepatocellular carcinoma with CD138 positivity

An unusual mimic of multiple myeloma?

Preetha Ramalingam, Bamidele Adeagbo, Roni Jacob Bollag, Jeffrey R Lee, Michelle Reid-Nicholson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

CD138 is a monoclonal anti-syndecan-1 antibody that is often used to identify plasma cells in the bone marrow of patients with multiple myeloma (MM). Several carcinomas may also express CD138 including prostate, colon, renal cell, and hepatocellular carcinoma (HCC). We report a case of metastatic HCC that presented as a soft tissue mass on the back of a 67-year-old male. Based on the clinical and radiologic findings, MM was strongly suspected. In addition, fine-needle aspiration biopsy (FNAB) of the mass revealed neoplastic cells that were positive for CD138, both by immunohistochemistry (IHC) and flow cytometry. The cytomorphologic features however did not support a diagnosis of MM, but were consistent with metastatic HCC. Our case highlights the potential problems that may arise by over-reliance on IHC and flow cytometry. Careful morphologic assessment as well as clinical and radiologic correlation are very important when evaluating any CD138-positive neoplasm. This approach should improve diagnostic accuracy and reduce the risk of erroneous interpretation of aberrant IHC results. In addition, we examined the expression of CD138 in known cases of HCC.

Original languageEnglish (US)
Pages (from-to)742-748
Number of pages7
JournalDiagnostic Cytopathology
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2008

Fingerprint

Multiple Myeloma
Hepatocellular Carcinoma
Immunohistochemistry
Flow Cytometry
Syndecan-1
Fine Needle Biopsy
Plasma Cells
Renal Cell Carcinoma
Prostate
Colon
Bone Marrow
Carcinoma
Antibodies
Neoplasms

Keywords

  • CD138
  • Fine-needle aspiration
  • Hepatocellular carcinoma
  • Multiple myeloma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Metastatic hepatocellular carcinoma with CD138 positivity : An unusual mimic of multiple myeloma? / Ramalingam, Preetha; Adeagbo, Bamidele; Bollag, Roni Jacob; Lee, Jeffrey R; Reid-Nicholson, Michelle.

In: Diagnostic Cytopathology, Vol. 36, No. 10, 01.10.2008, p. 742-748.

Research output: Contribution to journalArticle

Ramalingam, Preetha ; Adeagbo, Bamidele ; Bollag, Roni Jacob ; Lee, Jeffrey R ; Reid-Nicholson, Michelle. / Metastatic hepatocellular carcinoma with CD138 positivity : An unusual mimic of multiple myeloma?. In: Diagnostic Cytopathology. 2008 ; Vol. 36, No. 10. pp. 742-748.
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