@article{081b53fdcc374ff5a9d28c605b478bfd,
title = "Microneedle-Mediated Delivery of Lipid-Coated Cisplatin Nanoparticles for Efficient and Safe Cancer Therapy",
abstract = "Cisplatin is the first-line chemotherapeutic agent, but its systemic toxicity and side effects severely limit its clinical use. We report a microneedle technique to mediate the transdermal delivery of lipid-coated cisplatin nanoparticles (LCC-NPs) for efficient and safe cancer therapy. Cisplatin was encapsulated by tumor-targeting pH-responsive lipid nanoparticles with a high loading rate of 80%, and the encapsulation substantially increased the solubility of cisplatin and enhanced its antitumor efficiency in vitro. The LCC-NPs were embedded in dissolvable microneedles, and released from the microneedles after inserting into the skin. This enabled the nanoparticles to pass the stratum corneum for safe local delivery. An in vivo study with a xenograft tumor animal model demonstrated that microneedle arrays loaded with cisplatin nanoparticles significantly increased cytotoxicity and apoptosis in cancer cells with an apoptotic index of 58.6%, resulting in significantly reduced tumor volume and weight. Moreover, serum platinum, pulmonary toxicity, hepatotoxicity, and nephrotoxicity were not detected in vivo, indicating that this technique is biosafe. The cisplatin-nanoparticle microneedle system developed in this study may offer promising opportunities in cancer therapy for enhancing antitumor effects and reducing systemic toxicity and side effects.",
keywords = "cancer therapy, cisplatin, drug delivery, microneedle, nanoparticle",
author = "Xinmiao Lan and Juncong She and Lin, {Di An} and Yu Xu and Xuan Li and Yang, {Wei Fa} and Lui, {Vivian Wai Yan} and Lijian Jin and Xi Xie and Su, {Yu Xiong}",
note = "Funding Information: The project was supported by Hong Kong Research Grant Council General Research Fund no. 17120718 HKU Seed Fund for Basic Research nos. 201611159117 and 201511159130. X.X. would like to acknowledge financial support from the National Natural Science Foundation of China (grant no. 51705543, 61771498 and 31530023). V.W.Y.L. is funded by the Research Grant Council, Hong Kong (#17114814, #17121616, General Research Fund; and T12-401/13-R Theme-based Research Scheme), and the Hong Kong Cancer Fund, Hong Kong. J.S. would like to acknowledge finicial support from the Guangzhou Science Technology and Innovation Commission (grant no. 201607020012).We also appreciate HKU Li Ka Shing Faculty of Medicine Faculty Core Facility for the technical supports. Funding Information: The project was supported by Hong Kong Research Grant Council General Research Fund no. 17120718, HKU Seed Fund for Basic Research nos. 201611159117 and 201511159130. X.X. would like to acknowledge financial support from the National Natural Science Foundation of China (grant no. 51705543, 61771498 and 31530023). V.W.Y.L. is funded by the Research Grant Council, Hong Kong (#17114814, #17121616, General Research Fund; and T12-401/13-R Theme-based Research Scheme), and the Hong Kong Cancer Fund, Hong Kong. J.S. would like to acknowledge finicial support from the Guangzhou Science Technology and Innovation Commission (grant no. 201607020012). We also appreciate HKU Li Ka Shing Faculty of Medicine Faculty Core Facility for the technical supports. Publisher Copyright: {\textcopyright} Copyright 2018 American Chemical Society.",
year = "2018",
month = oct,
day = "3",
doi = "10.1021/acsami.8b12926",
language = "English (US)",
volume = "10",
pages = "33060--33069",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "39",
}