MicroRNA deficiency in pancreatic islet cells exacerbates streptozotocin-induced murine autoimmune diabetes

Qing Sheng Mi, Hong Zhi He, Zheng Dong, Carlos M Isales, Li Zhou

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Recent studies have demonstrated that gene expression is regulated not only by protein-coding genes, but also by non-protein-coding small RNA molecules, microRNAs (miRNAs). miRNAs have emerged as important regulators involved in many biological processes, including cell proliferation and differentiation, apoptosis and metabolism and disease development. Here we report that specific miRNA deficiency in pancreatic islet cells exacerbates multiple low-dose streptozotocin-induced murine autoimmune type 1 diabetes, suggesting that miRNAs expressed in islet β cells regulate their susceptibility to immune-mediated β cell destruction.

Original languageEnglish (US)
Pages (from-to)3199-3201
Number of pages3
JournalCell Cycle
Volume9
Issue number15
DOIs
StatePublished - Aug 1 2010

Keywords

  • Beta cells
  • Dicer
  • MicroRNAs
  • Streptozotocin
  • Type 1 diabetes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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