MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells

Matthew L. Potter, William D. Hill, Carlos M. Isales, Mark W. Hamrick, Sadanand Fulzele

Research output: Contribution to journalArticlepeer-review

Abstract

MicroRNAs (miRNAs) have recently come under scrutiny for their role in various age-related diseases. Similarly, cellular senescence has been linked to disease and aging. MicroRNAs and senescence likely play an intertwined role in driving these pathologic states. In this review, we present the connection between these two drivers of age-related disease concerning mesenchymal stem cells (MSCs). First, we summarize key miRNAs that are differentially expressed in MSCs and other musculoskeletal lineage cells during senescence and aging. Additionally, we also reviewed miRNAs that are regulated via traditional senescence-associated secretory phenotype (SASP) cytokines in MSC. Lastly, we summarize miRNAs that have been found to target components of the cell cycle arrest pathways inherently activated in senescence. This review attempts to highlight potential miRNA targets for regenerative medicine applications in age-related musculoskeletal disease.

Original languageEnglish (US)
Article number115679
JournalBone
Volume142
DOIs
StatePublished - Jan 2021

Keywords

  • Aging
  • Mesenchymal stem cells
  • MicroRNAs
  • Senescence

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Fingerprint Dive into the research topics of 'MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells'. Together they form a unique fingerprint.

Cite this