MicroRNAs as regulators of prostate cancer metastasis

Divya Bhagirath, Thao Ly Yang, Rajvir Dahiya, Sharanjot Saini

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Prostate cancer causes significant morbidity in men and metastatic disease is a major cause of cancer related deaths. Prostate metastasis is controlled by various cellular intrinsic and extrinsic factors, which are often under the regulatory control of various metastasis-associated genes. Given the dynamic nature of metastatic cancer cells, the various factors controlling this process are themselves regulated by microRNAs which are small non-coding RNAs. Significant research work has shown differential microRNA expression in primary and metastatic prostate cancer suggesting their importance in prostate pathogenesis. We will review the roles of different microRNAs in controlling the various steps in prostate metastasis.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages83-100
Number of pages18
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1095
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • ECM
  • EMT
  • Metastasis
  • Prostate cancer
  • microRNAs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Bhagirath, D., Yang, T. L., Dahiya, R., & Saini, S. (2018). MicroRNAs as regulators of prostate cancer metastasis. In Advances in Experimental Medicine and Biology (pp. 83-100). (Advances in Experimental Medicine and Biology; Vol. 1095). Springer New York LLC. https://doi.org/10.1007/978-3-319-95693-0_5