MicroRNAs in kidneys

Biogenesis, regulation, and pathophysiological roles

Kirti Bhatt, Qing Sheng Mi, Zheng Dong

Research output: Contribution to journalReview article

113 Citations (Scopus)

Abstract

MicroRNAs (miRNA) are endogenously produced, short RNAs that repress and thus regulate the expression of almost half of known protein-coding genes. miRNA-mediated gene repression is an important regulatory mechanism to modulate fundamental cellular processes such as the cell cycle, growth, proliferation, phenotype, and death, which in turn have major influences on pathophysiological outcomes. In kidneys, miRNAs are indispensable for renal development and homeostasis. Emerging evidence has further pinpointed the pathogenic roles played by miRNAs in major renal diseases, including diabetic nephropathy, acute kidney injury, renal carcinoma, polycystic kidney disease, and others. Although the field of renal miRNA research is still in its infancy and important questions remain, future investigation on miRNA regulation in kidneys has the potential to revolutionize both the diagnosis and treatment of major renal diseases.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Physiology
Volume300
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

MicroRNAs
Kidney
Polycystic Kidney Diseases
Diabetic Nephropathies
Acute Kidney Injury
Cell Cycle
Homeostasis
RNA
Carcinoma
Phenotype
Growth
Research
Genes
Proteins

Keywords

  • Acute kidney injury
  • Allograft rejection
  • Diabetic nephropathy
  • Dicer
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Physiology
  • Urology

Cite this

MicroRNAs in kidneys : Biogenesis, regulation, and pathophysiological roles. / Bhatt, Kirti; Mi, Qing Sheng; Dong, Zheng.

In: American Journal of Physiology - Renal Physiology, Vol. 300, No. 3, 01.03.2011.

Research output: Contribution to journalReview article

@article{2eaf1e2037cb46c492b8366c3198805d,
title = "MicroRNAs in kidneys: Biogenesis, regulation, and pathophysiological roles",
abstract = "MicroRNAs (miRNA) are endogenously produced, short RNAs that repress and thus regulate the expression of almost half of known protein-coding genes. miRNA-mediated gene repression is an important regulatory mechanism to modulate fundamental cellular processes such as the cell cycle, growth, proliferation, phenotype, and death, which in turn have major influences on pathophysiological outcomes. In kidneys, miRNAs are indispensable for renal development and homeostasis. Emerging evidence has further pinpointed the pathogenic roles played by miRNAs in major renal diseases, including diabetic nephropathy, acute kidney injury, renal carcinoma, polycystic kidney disease, and others. Although the field of renal miRNA research is still in its infancy and important questions remain, future investigation on miRNA regulation in kidneys has the potential to revolutionize both the diagnosis and treatment of major renal diseases.",
keywords = "Acute kidney injury, Allograft rejection, Diabetic nephropathy, Dicer, Renal cell carcinoma",
author = "Kirti Bhatt and Mi, {Qing Sheng} and Zheng Dong",
year = "2011",
month = "3",
day = "1",
doi = "10.1152/ajprenal.00727.2010",
language = "English (US)",
volume = "300",
journal = "American Journal of Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - MicroRNAs in kidneys

T2 - Biogenesis, regulation, and pathophysiological roles

AU - Bhatt, Kirti

AU - Mi, Qing Sheng

AU - Dong, Zheng

PY - 2011/3/1

Y1 - 2011/3/1

N2 - MicroRNAs (miRNA) are endogenously produced, short RNAs that repress and thus regulate the expression of almost half of known protein-coding genes. miRNA-mediated gene repression is an important regulatory mechanism to modulate fundamental cellular processes such as the cell cycle, growth, proliferation, phenotype, and death, which in turn have major influences on pathophysiological outcomes. In kidneys, miRNAs are indispensable for renal development and homeostasis. Emerging evidence has further pinpointed the pathogenic roles played by miRNAs in major renal diseases, including diabetic nephropathy, acute kidney injury, renal carcinoma, polycystic kidney disease, and others. Although the field of renal miRNA research is still in its infancy and important questions remain, future investigation on miRNA regulation in kidneys has the potential to revolutionize both the diagnosis and treatment of major renal diseases.

AB - MicroRNAs (miRNA) are endogenously produced, short RNAs that repress and thus regulate the expression of almost half of known protein-coding genes. miRNA-mediated gene repression is an important regulatory mechanism to modulate fundamental cellular processes such as the cell cycle, growth, proliferation, phenotype, and death, which in turn have major influences on pathophysiological outcomes. In kidneys, miRNAs are indispensable for renal development and homeostasis. Emerging evidence has further pinpointed the pathogenic roles played by miRNAs in major renal diseases, including diabetic nephropathy, acute kidney injury, renal carcinoma, polycystic kidney disease, and others. Although the field of renal miRNA research is still in its infancy and important questions remain, future investigation on miRNA regulation in kidneys has the potential to revolutionize both the diagnosis and treatment of major renal diseases.

KW - Acute kidney injury

KW - Allograft rejection

KW - Diabetic nephropathy

KW - Dicer

KW - Renal cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=79954468469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954468469&partnerID=8YFLogxK

U2 - 10.1152/ajprenal.00727.2010

DO - 10.1152/ajprenal.00727.2010

M3 - Review article

VL - 300

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 1931-857X

IS - 3

ER -