MicroRNAs in the development and progression of skin cancer

Vivek Choudhary, Meg Gullotto, Lisa Sato, Wendy B. Bollag

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MicroRNAs are known to regulate the messenger RNA (mRNA) levels and protein expression of multiple genes and their products by binding to the 3′ untranslated region (3′-UTR) of target mRNAs and causing their degradation or inhibiting their translation. Numerous reports have demonstrated the importance of microRNAs in skin biology, with microRNAs regulating multiple processes in the skin in vivo and in skin cells in vitro. Keratinocytes are the predominant cells of the outer layer of skin, the epidermis, and microRNAs have been shown to regulate proliferation, differentiation, apoptosis, senescence, migration/invasion, and morphogenesis of these cells. In addition, microRNAs modulate proteins involved in angiogenesis and genome stability, as well as immune function. Since dysregulation of all of these cellular processes can contribute to the development, progression, and metastasis of cancer, it is perhaps not surprising that recent studies are beginning to show alterations in microRNA profiles in different skin cancers. Thus, differences in various microRNAs have been detected in melanoma and in the nonmelanoma skin cancers, basal and squamous cell carcinoma. In this chapter, we discuss the literature indicating a role of microRNAs in regulating skin structure and function as well as in the development, progression, and metastasis of skin cancer, focusing primarily on the nonmelanoma skin cancers.

Original languageEnglish (US)
Title of host publicationMicroRNA in Development and in the Progression of Cancer
PublisherSpringer New York
Pages243-264
Number of pages22
ISBN (Electronic)9781489980656
ISBN (Print)1489980644, 9781489980649
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • (Cutaneous) squamous cell carcinoma
  • Basal cell carcinoma
  • Epidermis
  • Keratinocyte
  • Melanoma
  • MicroRNA
  • Nonmelanoma skin cancer
  • Skin cancer
  • p63

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Choudhary, V., Gullotto, M., Sato, L., & Bollag, W. B. (2014). MicroRNAs in the development and progression of skin cancer. In MicroRNA in Development and in the Progression of Cancer (pp. 243-264). Springer New York. https://doi.org/10.1007/978-1-4899-8065-6_13