Microtubule depolymerization facilitates contraction of vascular smooth muscle via increased activation of RhoA / Rho-kinase

K. Chitaley, R Clinton Webb

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The microtubule network is in a dynamic equilibrium between free and polymerized tubulin, with depolymerization resulting in increased cellular contractility (1-4). Originally, microtubule depolymerization was thought to facilitate contractile responses via the release of an internal, mechanical opposition to contraction. However, recent evidence suggests that depolymerization may also lead to the enhanced activity of various intracellular signaling proteins. The precise signaling pathway by which microtubule depolymerization facilitates vascular smooth muscle contraction is unknown. In non-vascular cells, depolymerization initiates stress fiber formation via increased activity of the small G-protein, RhoA (5-7). The role of this signaling candidate in a calcium-sensitizing contractile pathway is well established. We and others have found it tempting to speculate that RhoA mediates a contractile pathway enhanced by microtubule depolymerization. We further hypothesize the involvement of microtubule depolymerization (via RhoA and Rho-kinase) in the regulation of vascular smooth muscle contraction, with evidence of potential augmentations of this pathway contributing to the increased vasoconstrictor sensitivity seen in various hypertensive animal models.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalMedical Hypotheses
Volume56
Issue number3
DOIs
StatePublished - Jan 1 2001

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rho-Associated Kinases
Vascular Smooth Muscle
Microtubules
Muscle Contraction
Intracellular Signaling Peptides and Proteins
Stress Fibers
Monomeric GTP-Binding Proteins
Vasoconstrictor Agents
Tubulin
Animal Models
Calcium

ASJC Scopus subject areas

  • Medicine(all)

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Microtubule depolymerization facilitates contraction of vascular smooth muscle via increased activation of RhoA / Rho-kinase. / Chitaley, K.; Webb, R Clinton.

In: Medical Hypotheses, Vol. 56, No. 3, 01.01.2001, p. 381-385.

Research output: Contribution to journalArticle

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