Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed

Romulo Leite, R Clinton Webb

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The pressor response induced by phenylephrine in the rat isolated mesenteric arterial bed was significantly increased following treatment with nocodazole, a drug that disassembles microtubules (10 μM, 90 min). This increase was even greater in the presence of nitric oxide (NO) synthase inhibition, and completely reversed by paclitaxel (20 μM), a stabilizer of microtubules. These results demonstrate that disassembly of microtubules enhances vasoconstriction to receptor activation, suggesting that the microtubules modulate the transduction of intracellular signals in endothelium and vascular smooth muscle cells.

Original languageEnglish (US)
JournalEuropean Journal of Pharmacology
Volume351
Issue number1
DOIs
StatePublished - Jun 12 1998
Externally publishedYes

Fingerprint

Phenylephrine
Vasoconstriction
Microtubules
Nocodazole
Paclitaxel
Vascular Smooth Muscle
Nitric Oxide Synthase
Smooth Muscle Myocytes
Endothelium
Signal Transduction
Pharmaceutical Preparations

Keywords

  • Blood vessel
  • Microtubule
  • Nocodazole

ASJC Scopus subject areas

  • Pharmacology

Cite this

Microtubule disruption potentiates phenylephrine-induced vasoconstriction in rat mesenteric arterial bed. / Leite, Romulo; Webb, R Clinton.

In: European Journal of Pharmacology, Vol. 351, No. 1, 12.06.1998.

Research output: Contribution to journalArticle

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