@article{a9eaedd1010f486893c5a092a5f5fa38,
title = "Middle Ear Effusion in Children with Congenital Cytomegalovirus Infection",
abstract = "Background: Sensorineural hearing loss (SNHL) is well described in children with congenital cytomegalovirus (CMV) infection, but limited data are available on middle ear effusion (MEE) occurrence in this population. We assessed the prevalence of MEE and the degree of transient hearing change associated with MEE among children with congenital CMV infection. Methods: Children with congenital CMV infection enrolled in a longitudinal study received hearing and tympanometric testing during scheduled follow-up visits annually up to 6 years of age. We used a generalized linear mixed-effect logistic regression model to compare the odds of MEE, defined as type B tympanogram (normal ear canal volume with little tympanic membrane movement) among patients categorized as symptomatic or asymptomatic based on the presence of congenital CMV-associated signs in the newborn period. Results: Forty-four (61%) of 72 symptomatic and 24 (28%) of 87 asymptomatic patients had ≥1 visit with MEE. After controlling for the number of visits, symptomatic patients had significantly higher odds of MEE (odds ratio: 2.09; 95% confidence interval: 1.39-3.14) than asymptomatic patients. Transient hearing decrease associated with a type B tympanogram ranged from 10 to 40 dB, as measured by audiometric air-bone gap in 11 patients. Conclusions: Among children with congenital CMV, MEE can result in transient hearing decrease, which can reduce the efficacy of a hearing aid in those with SNHL. It is warranted that children with congenital CMV infection and SNHL receive routine audiologic and tympanometric testing to better manage hearing aid amplification levels.",
keywords = "congenital cytomegalovirus infection, hearing loss, middle ear effusion, tympanometry",
author = "{Congenital Cytomegalovirus Longitudinal Study Group} and Winnie Chung and Jessica Leung and Lanzieri, {Tatiana M.} and Peggy Blum and Gail Demmler-Harrison and Shahzad Ahmed and Hanna Baer and Bhatt, {Amit R.} and Frank Brown and Francis Catlin and Caviness, {Alison C.} and Coats, {David K.} and Edmonds, {Jane C.} and Marily Flores and Daniel Franklin and Cindy Gandaria and Jewel Greer and Carol Griesser and Hussein, {Mohamed A.} and Isabella Iovino and Allison Istas and Jin, {Haoxing Douglas} and Kelinske, {Mary K.} and Klingen, {Joseph T.} and Antone Laurente and Thomas Littman and Mary Murphy and Jerry Miller and Christopher Nelson and Daniel Noyola and Paysse, {Evelyn A.} and Alan Percy and Sara Reis and Ann Reynolds and Judith Rozelle and O'Brien Smith and Paul Steinkuller and Marie Turcich and Vinson, {Sherry Sellers} and Voigt, {Robert G.} and Bethann Walmus and Jill Williams and Daniel Williamson and Yen, {Kimberly G.} and Yow, {Martha D.}",
note = "Funding Information: Supported, in part, by the CMV Research Fund Donors at Baylor College of Medicine; the Woman{\textquoteright}s Hospital of Texas Research Foundation; the Office of Research Resources and the General Clinical Research Center for Children at Texas Children{\textquoteright}s Hospital and Baylor College of Medicine (NIH 5M0I RR00188-33); the Mental Retardation Research Center at Baylor College of Medicine (NIH-CHHD 5 P30 HD24064P); the Research to Prevent Blind-ness, Inc. New York, NY; the Deafness Foundation, Houston, TX; the Vale Ashe Foundation, Houston, TX; the Maddie{\textquoteright}s Mission Foundation, Katy, TX; the Naymola Foundation, Beaumont, TX; the American Pediatric Society-Society for Pediatric Research Summer Student Research Program (NIH-CHHD) and the Centers for Disease Control and Prevention (Cooperative Agreement FOA IP 10-006). Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = apr,
day = "1",
doi = "10.1097/INF.0000000000002564",
language = "English (US)",
volume = "39",
pages = "273--276",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "4",
}