Minocycline for short-term neuroprotection

Hazem F. Elewa, Rend Hilali, David C Hess, Livia S. Machado, Susan C. Fagan

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Minocycline is a widely used tetracycline antibiotic. For decades, it has been used to treat various gram-positive and gram-negative infections. Minocycline was recently shown to have neuroprotective properties in animal models of acute neurologic injury. As a neuroprotective agent, the drug appears more effective than other treatment options. In addition to its high penetration of the blood-brain barrier, minocycline is a safe compound commonly used to treat chronic infections. Its several mechanisms of action in neuroprotection-antiinflammatory and antiapoptotic effects, and protease inhibition-make it a desirable candidate as therapy for acute neurologic injury, such as ischemic stroke. Minocycline is ready for clinical trials of acute neurologic injury.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalPharmacotherapy
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Minocycline
Nervous System Trauma
Neuroprotective Agents
Infection
Tetracycline
Blood-Brain Barrier
Peptide Hydrolases
Anti-Inflammatory Agents
Animal Models
Stroke
Clinical Trials
Anti-Bacterial Agents
Neuroprotection
Therapeutics

Keywords

  • Minocycline
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Elewa, H. F., Hilali, R., Hess, D. C., Machado, L. S., & Fagan, S. C. (2006). Minocycline for short-term neuroprotection. Pharmacotherapy, 26(4), 515-521. https://doi.org/10.1592/phco.26.4.515

Minocycline for short-term neuroprotection. / Elewa, Hazem F.; Hilali, Rend; Hess, David C; Machado, Livia S.; Fagan, Susan C.

In: Pharmacotherapy, Vol. 26, No. 4, 01.04.2006, p. 515-521.

Research output: Contribution to journalArticle

Elewa, HF, Hilali, R, Hess, DC, Machado, LS & Fagan, SC 2006, 'Minocycline for short-term neuroprotection', Pharmacotherapy, vol. 26, no. 4, pp. 515-521. https://doi.org/10.1592/phco.26.4.515
Elewa HF, Hilali R, Hess DC, Machado LS, Fagan SC. Minocycline for short-term neuroprotection. Pharmacotherapy. 2006 Apr 1;26(4):515-521. https://doi.org/10.1592/phco.26.4.515
Elewa, Hazem F. ; Hilali, Rend ; Hess, David C ; Machado, Livia S. ; Fagan, Susan C. / Minocycline for short-term neuroprotection. In: Pharmacotherapy. 2006 ; Vol. 26, No. 4. pp. 515-521.
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