Abstract
Minocycline is a widely used tetracycline antibiotic. For decades, it has been used to treat various gram-positive and gram-negative infections. Minocycline was recently shown to have neuroprotective properties in animal models of acute neurologic injury. As a neuroprotective agent, the drug appears more effective than other treatment options. In addition to its high penetration of the blood-brain barrier, minocycline is a safe compound commonly used to treat chronic infections. Its several mechanisms of action in neuroprotection-antiinflammatory and antiapoptotic effects, and protease inhibition-make it a desirable candidate as therapy for acute neurologic injury, such as ischemic stroke. Minocycline is ready for clinical trials of acute neurologic injury.
Original language | English (US) |
---|---|
Pages (from-to) | 515-521 |
Number of pages | 7 |
Journal | Pharmacotherapy |
Volume | 26 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2006 |
Keywords
- Minocycline
- Neuroprotection
- Stroke
ASJC Scopus subject areas
- Pharmacology (medical)