Minocycline for short-term neuroprotection

Hazem F. Elewa, Rend Hilali, David C. Hess, Livia S. Machado, Susan C. Fagan

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

Minocycline is a widely used tetracycline antibiotic. For decades, it has been used to treat various gram-positive and gram-negative infections. Minocycline was recently shown to have neuroprotective properties in animal models of acute neurologic injury. As a neuroprotective agent, the drug appears more effective than other treatment options. In addition to its high penetration of the blood-brain barrier, minocycline is a safe compound commonly used to treat chronic infections. Its several mechanisms of action in neuroprotection-antiinflammatory and antiapoptotic effects, and protease inhibition-make it a desirable candidate as therapy for acute neurologic injury, such as ischemic stroke. Minocycline is ready for clinical trials of acute neurologic injury.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalPharmacotherapy
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2006

Keywords

  • Minocycline
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Pharmacology (medical)

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    Elewa, H. F., Hilali, R., Hess, D. C., Machado, L. S., & Fagan, S. C. (2006). Minocycline for short-term neuroprotection. Pharmacotherapy, 26(4), 515-521. https://doi.org/10.1592/phco.26.4.515