Minocycline-induced black bone disease encountered during total knee arthroplasty

Dale N. Reed, Frederick O. Gregg, R. Scott Corpe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Finding discolored bone intraoperatively can be confusing and concerning to orthopedic surgeons. Multiple causes of pigmented bone exist, including ochronosis, metabolic bone diseases, metal deposits, sequestrum, metastatic disease, and minocycline use. Bone quality is an important consideration in intraoperative decision making with respect to components and fixation options in total joint arthroplasty. Abnormal bone encountered in routine arthroplasty can raise concerns over the integrity and healing potential of the bone when the etiology is uncertain. Minocycline is a drug routinely used for the treatment of acne, rosacea, and rheumatoid arthritis. Pigmentation is a commonly recognized adverse reaction associated with most of the drugs in the tetracycline family, affecting the skin, nails, teeth, oral mucosa, bones in the oral cavity, ocular structures, cartilage, thyroid, and other visceral structures. This article describes a case of pigmented bone secondary to minocycline use in a 55-year-old woman undergoing total knee arthroplasty. This entity has rarely been documented in the orthopedic literature; however, orthopedic surgeons should be aware of this side effect secondary to the widespread use of minocycline. Questions concerning the effect of minocycline on bone metabolism and structural integrity have yet to be fully answered, but an understanding and recognition of the entity will help guide surgeons with intraoperative decision making.

Original languageEnglish (US)
Pages (from-to)e737-e739
JournalOrthopedics
Volume35
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Knee Replacement Arthroplasties
Minocycline
Bone Diseases
Bone and Bones
Arthroplasty
Decision Making
Ochronosis
Thyroid Cartilage
Rosacea
Metabolic Bone Diseases
Pigmentation
Mouth Mucosa
Nails
Tetracycline
Pharmaceutical Preparations
Orthopedics
Mouth
Rheumatoid Arthritis
Tooth
Joints

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Minocycline-induced black bone disease encountered during total knee arthroplasty. / Reed, Dale N.; Gregg, Frederick O.; Corpe, R. Scott.

In: Orthopedics, Vol. 35, No. 5, 01.05.2012, p. e737-e739.

Research output: Contribution to journalArticle

Reed, Dale N. ; Gregg, Frederick O. ; Corpe, R. Scott. / Minocycline-induced black bone disease encountered during total knee arthroplasty. In: Orthopedics. 2012 ; Vol. 35, No. 5. pp. e737-e739.
@article{066ec6a964444f8c91c5faacd7595d41,
title = "Minocycline-induced black bone disease encountered during total knee arthroplasty",
abstract = "Finding discolored bone intraoperatively can be confusing and concerning to orthopedic surgeons. Multiple causes of pigmented bone exist, including ochronosis, metabolic bone diseases, metal deposits, sequestrum, metastatic disease, and minocycline use. Bone quality is an important consideration in intraoperative decision making with respect to components and fixation options in total joint arthroplasty. Abnormal bone encountered in routine arthroplasty can raise concerns over the integrity and healing potential of the bone when the etiology is uncertain. Minocycline is a drug routinely used for the treatment of acne, rosacea, and rheumatoid arthritis. Pigmentation is a commonly recognized adverse reaction associated with most of the drugs in the tetracycline family, affecting the skin, nails, teeth, oral mucosa, bones in the oral cavity, ocular structures, cartilage, thyroid, and other visceral structures. This article describes a case of pigmented bone secondary to minocycline use in a 55-year-old woman undergoing total knee arthroplasty. This entity has rarely been documented in the orthopedic literature; however, orthopedic surgeons should be aware of this side effect secondary to the widespread use of minocycline. Questions concerning the effect of minocycline on bone metabolism and structural integrity have yet to be fully answered, but an understanding and recognition of the entity will help guide surgeons with intraoperative decision making.",
author = "Reed, {Dale N.} and Gregg, {Frederick O.} and Corpe, {R. Scott}",
year = "2012",
month = "5",
day = "1",
doi = "10.3928/01477447-20120426-30",
language = "English (US)",
volume = "35",
pages = "e737--e739",
journal = "Orthopedics",
issn = "0147-7447",
publisher = "Slack Incorporated",
number = "5",

}

TY - JOUR

T1 - Minocycline-induced black bone disease encountered during total knee arthroplasty

AU - Reed, Dale N.

AU - Gregg, Frederick O.

AU - Corpe, R. Scott

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Finding discolored bone intraoperatively can be confusing and concerning to orthopedic surgeons. Multiple causes of pigmented bone exist, including ochronosis, metabolic bone diseases, metal deposits, sequestrum, metastatic disease, and minocycline use. Bone quality is an important consideration in intraoperative decision making with respect to components and fixation options in total joint arthroplasty. Abnormal bone encountered in routine arthroplasty can raise concerns over the integrity and healing potential of the bone when the etiology is uncertain. Minocycline is a drug routinely used for the treatment of acne, rosacea, and rheumatoid arthritis. Pigmentation is a commonly recognized adverse reaction associated with most of the drugs in the tetracycline family, affecting the skin, nails, teeth, oral mucosa, bones in the oral cavity, ocular structures, cartilage, thyroid, and other visceral structures. This article describes a case of pigmented bone secondary to minocycline use in a 55-year-old woman undergoing total knee arthroplasty. This entity has rarely been documented in the orthopedic literature; however, orthopedic surgeons should be aware of this side effect secondary to the widespread use of minocycline. Questions concerning the effect of minocycline on bone metabolism and structural integrity have yet to be fully answered, but an understanding and recognition of the entity will help guide surgeons with intraoperative decision making.

AB - Finding discolored bone intraoperatively can be confusing and concerning to orthopedic surgeons. Multiple causes of pigmented bone exist, including ochronosis, metabolic bone diseases, metal deposits, sequestrum, metastatic disease, and minocycline use. Bone quality is an important consideration in intraoperative decision making with respect to components and fixation options in total joint arthroplasty. Abnormal bone encountered in routine arthroplasty can raise concerns over the integrity and healing potential of the bone when the etiology is uncertain. Minocycline is a drug routinely used for the treatment of acne, rosacea, and rheumatoid arthritis. Pigmentation is a commonly recognized adverse reaction associated with most of the drugs in the tetracycline family, affecting the skin, nails, teeth, oral mucosa, bones in the oral cavity, ocular structures, cartilage, thyroid, and other visceral structures. This article describes a case of pigmented bone secondary to minocycline use in a 55-year-old woman undergoing total knee arthroplasty. This entity has rarely been documented in the orthopedic literature; however, orthopedic surgeons should be aware of this side effect secondary to the widespread use of minocycline. Questions concerning the effect of minocycline on bone metabolism and structural integrity have yet to be fully answered, but an understanding and recognition of the entity will help guide surgeons with intraoperative decision making.

UR - http://www.scopus.com/inward/record.url?scp=84861508124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861508124&partnerID=8YFLogxK

U2 - 10.3928/01477447-20120426-30

DO - 10.3928/01477447-20120426-30

M3 - Article

C2 - 22588418

AN - SCOPUS:84861508124

VL - 35

SP - e737-e739

JO - Orthopedics

JF - Orthopedics

SN - 0147-7447

IS - 5

ER -