TY - JOUR
T1 - MiR-17-92 cluster is a novel regulatory gene of cardiac ischemic/reperfusion injury
AU - Zhou, Mi
AU - Cai, Junfeng
AU - Tang, Yao Liang
AU - Zhao, Qiang
PY - 2013/7
Y1 - 2013/7
N2 - The miR-17-92 cluster is an important microRNA cluster in the animals. It was mainly investigated as an oncogene in tumors but never studied in cardiovascular disease. On one aspect, miR-17-92 cluster is documented to play anti-apoptotic roles in tumor cells, including hypoxia-induced apoptosis. The families of miR-17, miR-19, and miR-92 promote resistance to apoptosis by directly inhibiting pro-apoptotic protein, and by the two major cell survival signaling pathways-PI3K/AKT, and MAPK/ERK. On the other aspect, the component members of miR-17-92 cluster are high expressed in the hearts of canine and mice, suggesting that there are effect targets of the cluster in the myocardium. So that, we hypothesized that the miR-17-92 cluster may protect the heart by diminishing the apoptosis and alleviating ischemia/reperfusion injury. This may be a new regulating target for patients with myocardial infarction and undergoing cardiac surgery.
AB - The miR-17-92 cluster is an important microRNA cluster in the animals. It was mainly investigated as an oncogene in tumors but never studied in cardiovascular disease. On one aspect, miR-17-92 cluster is documented to play anti-apoptotic roles in tumor cells, including hypoxia-induced apoptosis. The families of miR-17, miR-19, and miR-92 promote resistance to apoptosis by directly inhibiting pro-apoptotic protein, and by the two major cell survival signaling pathways-PI3K/AKT, and MAPK/ERK. On the other aspect, the component members of miR-17-92 cluster are high expressed in the hearts of canine and mice, suggesting that there are effect targets of the cluster in the myocardium. So that, we hypothesized that the miR-17-92 cluster may protect the heart by diminishing the apoptosis and alleviating ischemia/reperfusion injury. This may be a new regulating target for patients with myocardial infarction and undergoing cardiac surgery.
UR - http://www.scopus.com/inward/record.url?scp=84878592687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878592687&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2013.03.043
DO - 10.1016/j.mehy.2013.03.043
M3 - Article
C2 - 23639284
AN - SCOPUS:84878592687
SN - 0306-9877
VL - 81
SP - 108
EP - 110
JO - Medical Hypotheses
JF - Medical Hypotheses
IS - 1
ER -