Abstract
This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.
Original language | English (US) |
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Pages (from-to) | 246-254 |
Number of pages | 9 |
Journal | FEBS Letters |
Volume | 589 |
Issue number | 2 |
DOIs | |
State | Published - Jan 16 2015 |
Externally published | Yes |
Keywords
- Coxsackie B virus
- Coxsackie virus and Adenovirus Receptor
- microRNA
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology