MiR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor

W. Y. Lam, Ariel C.Y. Cheung, Christine K.C. Tung, Apple C.M. Yeung, Karry L.K. Ngai, Vivian W.Y. Lui, Paul K.S. Chan, Stephen K.W. Tsui

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.

Original languageEnglish (US)
Pages (from-to)246-254
Number of pages9
JournalFEBS Letters
Volume589
Issue number2
DOIs
StatePublished - Jan 16 2015
Externally publishedYes

Keywords

  • Coxsackie B virus
  • Coxsackie virus and Adenovirus Receptor
  • microRNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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