Mitochondrial dynamics: Regulatory mechanisms and emerging role in renal pathophysiology

Ming Zhan, Craig Brooks, Fuyou Liu, Lin Sun, Zheng Dong

Research output: Contribution to journalReview article

156 Scopus citations

Abstract

Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion. Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by regulatory proteins. During cell injury or stress, the dynamics is shifted to fission, resulting in mitochondrial fragmentation, which contributes to mitochondrial damage and consequent cell injury and death. Emerging evidence has suggested a role of mitochondrial fragmentation in the pathogenesis of renal diseases including acute kidney injury and diabetic nephropathy. A better understanding of the regulation of mitochondrial dynamics and its pathogenic changes may unveil novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)568-581
Number of pages14
JournalKidney International
Volume83
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • acute renal failure
  • apoptosis
  • mitochondria

ASJC Scopus subject areas

  • Nephrology

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