Mitochondrial dysregulation and protection in cisplatin nephrotoxicity

Yuan Yang, Hong Liu, Fuyou Liu, Zheng Dong

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy.

Original languageEnglish (US)
Pages (from-to)1249-1256
Number of pages8
JournalArchives of Toxicology
Volume88
Issue number6
DOIs
StatePublished - Jan 1 2014

Keywords

  • Apoptosis
  • Cisplatin
  • Mitochondria
  • Nephrotoxicity
  • Reactive oxygen species

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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