Abstract
Prior to weaning, medium-chain fatty acids constitute an important energy source in the developing rat. Fatty acid oxidation rates increase with age in most developing tissues, but the pattern of this increase may vary according to the role of the particular organ. In skeletal muscle, heart, and liver of developing rats, we measured mitochondrial activities of long- and short-chain enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and long- and short-chain acyl-CoA thiolase. In skeletal muscle, the pattern of development in fatty acid oxidation enzymes favored utilization of long-chain rather than medium-chain fatty acids. In liver, enzyme activities for medium-chain fatty acids were highest prior to weaning. Heart occupied a position intermediate between skeletal muscle and liver.
Original language | English (US) |
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Pages (from-to) | 410-414 |
Number of pages | 5 |
Journal | The Journal of Nutritional Biochemistry |
Volume | 1 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1990 |
Keywords
- 3-hydroxyacyl-CoA dehydrogenase
- enoyl CoA hydratase
- heart
- liver
- rat
- skeletal muscle
- thiolase
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Biology
- Nutrition and Dietetics
- Clinical Biochemistry