Mitogen-Activated Protein Kinases in Endothelial Pathophysiology

Natalia V. Bogatcheva, Steven M. Dudek, Joe G.N. Garcia, Alexander D. Verin

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Endothelial cells continuously respond to extracellular stimuli such as chemical signals produced by circulating blood elements or mechanical forces such as shear stress. Proinflammatory cytokines, mitogens, reactive oxygen species, and shear stress trigger signal molecules to initiate multiple intracellular pathways, which often converge at mitogen-activated protein (MAP) kinase activation. The MAP kinase superfamily represents a burgeoning area of clinical investigation for treatment of various inflammatory and oncologic diseases and plays an essential role in mediating response to infection, ischemia/reperfusion injury, and vessel healing and remodeling through regulation of such diverse phenomena as endothelial cell proliferation, migration, apoptosis, and endothelial barrier function. The downstream effects of MAP kinase activation include modulation of gene expression via up-regulation of various transcription factors. In addition to these sustained effects, MAP kinases coordinate more immediate responses that affect dynamic cytoskeletal rearrangements necessary for cell migration and regulation of barrier function. This review discusses the important regulatory roles of MAP kinases in the vital physiologic functions of endothelium, focusing mainly on the role of MAP kinases in the maintenance of endothelial barrier.

Original languageEnglish (US)
Pages (from-to)341-352
Number of pages12
JournalJournal of Investigative Medicine
Volume51
Issue number6
StatePublished - Nov 2003

Fingerprint

Mitogen-Activated Protein Kinases
Endothelial cells
Cell Movement
Shear stress
Endothelial Cells
Chemical activation
Cell proliferation
Reperfusion Injury
Mitogens
Gene expression
Chemical elements
Endothelium
Reactive Oxygen Species
Blood
Transcription Factors
Up-Regulation
Maintenance
Cell Proliferation
Modulation
Apoptosis

Keywords

  • Endothelium
  • MAP kinase
  • Permeability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bogatcheva, N. V., Dudek, S. M., Garcia, J. G. N., & Verin, A. D. (2003). Mitogen-Activated Protein Kinases in Endothelial Pathophysiology. Journal of Investigative Medicine, 51(6), 341-352.

Mitogen-Activated Protein Kinases in Endothelial Pathophysiology. / Bogatcheva, Natalia V.; Dudek, Steven M.; Garcia, Joe G.N.; Verin, Alexander D.

In: Journal of Investigative Medicine, Vol. 51, No. 6, 11.2003, p. 341-352.

Research output: Contribution to journalReview article

Bogatcheva, NV, Dudek, SM, Garcia, JGN & Verin, AD 2003, 'Mitogen-Activated Protein Kinases in Endothelial Pathophysiology', Journal of Investigative Medicine, vol. 51, no. 6, pp. 341-352.
Bogatcheva, Natalia V. ; Dudek, Steven M. ; Garcia, Joe G.N. ; Verin, Alexander D. / Mitogen-Activated Protein Kinases in Endothelial Pathophysiology. In: Journal of Investigative Medicine. 2003 ; Vol. 51, No. 6. pp. 341-352.
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