Mitophagy in Acute Kidney Injury and Kidney Repair

Ying Wang, Juan Cai, Chengyuan Tang, Zheng Dong

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Acute kidney injury (AKI) is a major kidney disease characterized by rapid decline of renal function. Besides its acute consequence of high mortality, AKI has recently been recognized as an independent risk factor for chronic kidney disease (CKD). Maladaptive or incomplete repair of renal tubules after severe or episodic AKI leads to renal fibrosis and, eventually, CKD. Recent studies highlight a key role of mitochondrial pathology in AKI development and abnormal kidney repair after AKI. As such, timely elimination of damaged mitochondria in renal tubular cells represents an important quality control mechanism for cell homeostasis and survival during kidney injury and repair. Mitophagy is a selective form of autophagy that selectively removes redundant or damaged mitochondria. Here, we summarize our recent understanding on the molecular mechanisms of mitophagy, discuss the role of mitophagy in AKI development and kidney repair after AKI, and present future research directions and therapeutic potential.

Original languageEnglish (US)
JournalCells
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • acute kidney injury
  • kidney repair
  • mitochondria
  • mitophagy

ASJC Scopus subject areas

  • Medicine(all)

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