Mobile fiber-optic sensor for detection of oral and cervical cancer in the developing world

Bing Yu, Vivek Krishna Nagarajan, Daron Gale Ferris

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Oral and cervical cancers are a growing global health problem that disproportionately impacts women and men living in the developing world. The high death rate in developing countries is largely due to the fact that these countries do not have the appropriate medical infrastructure and resources to support the organized screening and diagnostic programs that are available in the developed world. Diffuse reflectance spectroscopy (DRS) with a fiber-optic probe can noninvasively quantify the optical properties of epithelial tissues and has shown the potential as a cost-effective, easy-to-use, and sensitive tool for diagnosis of early precancerous changes in the cervix and oral cavity. However, current fiber-optic DRS systems have not been designed to be robust and reliable for use in developing countries. They are subject to various sources of systematic or random errors, arising from the uncontrolled probe-tissue interface and lack of real-time calibration, use bulky and expensive optical components, and require extensive training. This chapter describes a portable DRS device that is specifically designed for detection of oral and cervical cancers in resource-poor settings. The device uses an innovative smart fiber-optic probe to eliminate operator bias, state-of-the-art photonics components to reduce size and power consumption, and automated software to reduce the need of operator training. The size and cost of the smart fiber-optic DRS system may be further reduced by incorporating a smartphone based spectrometer.

Original languageEnglish (US)
Pages (from-to)155-170
Number of pages16
JournalMethods in Molecular Biology
Volume1256
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Mouth Neoplasms
Uterine Cervical Neoplasms
Spectrum Analysis
Developing Countries
Optics and Photonics
Costs and Cost Analysis
Equipment and Supplies
Optical Devices
Cervix Uteri
Calibration
Mouth
Software
Epithelium
Mortality

Keywords

  • Diffuse reflectance spectroscopy
  • Fiber-optic sensor
  • Oral and cervical cancers
  • Smartphone

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Mobile fiber-optic sensor for detection of oral and cervical cancer in the developing world. / Yu, Bing; Nagarajan, Vivek Krishna; Ferris, Daron Gale.

In: Methods in Molecular Biology, Vol. 1256, 01.01.2015, p. 155-170.

Research output: Contribution to journalArticle

@article{8c68681b57fd43da89bc1291a97d65c7,
title = "Mobile fiber-optic sensor for detection of oral and cervical cancer in the developing world",
abstract = "Oral and cervical cancers are a growing global health problem that disproportionately impacts women and men living in the developing world. The high death rate in developing countries is largely due to the fact that these countries do not have the appropriate medical infrastructure and resources to support the organized screening and diagnostic programs that are available in the developed world. Diffuse reflectance spectroscopy (DRS) with a fiber-optic probe can noninvasively quantify the optical properties of epithelial tissues and has shown the potential as a cost-effective, easy-to-use, and sensitive tool for diagnosis of early precancerous changes in the cervix and oral cavity. However, current fiber-optic DRS systems have not been designed to be robust and reliable for use in developing countries. They are subject to various sources of systematic or random errors, arising from the uncontrolled probe-tissue interface and lack of real-time calibration, use bulky and expensive optical components, and require extensive training. This chapter describes a portable DRS device that is specifically designed for detection of oral and cervical cancers in resource-poor settings. The device uses an innovative smart fiber-optic probe to eliminate operator bias, state-of-the-art photonics components to reduce size and power consumption, and automated software to reduce the need of operator training. The size and cost of the smart fiber-optic DRS system may be further reduced by incorporating a smartphone based spectrometer.",
keywords = "Diffuse reflectance spectroscopy, Fiber-optic sensor, Oral and cervical cancers, Smartphone",
author = "Bing Yu and Nagarajan, {Vivek Krishna} and Ferris, {Daron Gale}",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-2172-0_11",
language = "English (US)",
volume = "1256",
pages = "155--170",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",

}

TY - JOUR

T1 - Mobile fiber-optic sensor for detection of oral and cervical cancer in the developing world

AU - Yu, Bing

AU - Nagarajan, Vivek Krishna

AU - Ferris, Daron Gale

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Oral and cervical cancers are a growing global health problem that disproportionately impacts women and men living in the developing world. The high death rate in developing countries is largely due to the fact that these countries do not have the appropriate medical infrastructure and resources to support the organized screening and diagnostic programs that are available in the developed world. Diffuse reflectance spectroscopy (DRS) with a fiber-optic probe can noninvasively quantify the optical properties of epithelial tissues and has shown the potential as a cost-effective, easy-to-use, and sensitive tool for diagnosis of early precancerous changes in the cervix and oral cavity. However, current fiber-optic DRS systems have not been designed to be robust and reliable for use in developing countries. They are subject to various sources of systematic or random errors, arising from the uncontrolled probe-tissue interface and lack of real-time calibration, use bulky and expensive optical components, and require extensive training. This chapter describes a portable DRS device that is specifically designed for detection of oral and cervical cancers in resource-poor settings. The device uses an innovative smart fiber-optic probe to eliminate operator bias, state-of-the-art photonics components to reduce size and power consumption, and automated software to reduce the need of operator training. The size and cost of the smart fiber-optic DRS system may be further reduced by incorporating a smartphone based spectrometer.

AB - Oral and cervical cancers are a growing global health problem that disproportionately impacts women and men living in the developing world. The high death rate in developing countries is largely due to the fact that these countries do not have the appropriate medical infrastructure and resources to support the organized screening and diagnostic programs that are available in the developed world. Diffuse reflectance spectroscopy (DRS) with a fiber-optic probe can noninvasively quantify the optical properties of epithelial tissues and has shown the potential as a cost-effective, easy-to-use, and sensitive tool for diagnosis of early precancerous changes in the cervix and oral cavity. However, current fiber-optic DRS systems have not been designed to be robust and reliable for use in developing countries. They are subject to various sources of systematic or random errors, arising from the uncontrolled probe-tissue interface and lack of real-time calibration, use bulky and expensive optical components, and require extensive training. This chapter describes a portable DRS device that is specifically designed for detection of oral and cervical cancers in resource-poor settings. The device uses an innovative smart fiber-optic probe to eliminate operator bias, state-of-the-art photonics components to reduce size and power consumption, and automated software to reduce the need of operator training. The size and cost of the smart fiber-optic DRS system may be further reduced by incorporating a smartphone based spectrometer.

KW - Diffuse reflectance spectroscopy

KW - Fiber-optic sensor

KW - Oral and cervical cancers

KW - Smartphone

UR - http://www.scopus.com/inward/record.url?scp=84922058868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922058868&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-2172-0_11

DO - 10.1007/978-1-4939-2172-0_11

M3 - Article

C2 - 25626538

AN - SCOPUS:84922058868

VL - 1256

SP - 155

EP - 170

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

ER -