Mobility, mood and site of care impact health related quality of life in Parkinson's disease

J. G. Nutt, A. D. Siderowf, M. Guttman, P. N. Schmidt, J. I. Zamudio, S. S. Wu, M. S. Okun, T. Simuni, S. A. Parashos, N. A. Dahodwala, T. L. Davis, N. Giladi, T. Gurevich, R. A. Hauser, J. Jankovic, K. E. Lyons, L. Marsh, J. M. Miyasaki, John Christopher Morgan, A. J. SantiagoD. Tarsy, Z. Mari, I. A. Malaty, E. C. Nelson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Examine the correlates of Health Related Quality of Life (HRQL) in a large cohort of Parkinson's disease (PD) patients from National Parkinson Foundation (NPF) Centers of Excellence (COEs). Background: Improving outcomes for PD will depend upon uncovering disease features impacting HRQL to identify targets for intervention and variables for risk-adjustment models. Differences in HRQL outcomes between COEs could uncover modifiable aspects of care delivery. Methods: This cross-sectional study examined the relative contribution of demographic, social, clinical and treatment features potentially related to HRQL, as measured by the PDQ-39, in 4601 consecutive subjects from 18 COEs. Stepwise linear regression was utilized to identify correlates of HRQL. Results: The variability in the PDQ-39 summary index score correlated with H&Y stage (R2=22%), Timed up and Go (TUG) (17%), disease duration (11%), comorbidities (8%), cognitive status (8%), antidepressant use (6%) and center at which a patient received care (5%). Stepwise regression reordered the importance of the variables, with the H&Y first and TUG and the center becoming equal and the second most important variables determining the PDQ-39 total score. All independent variables together accounted for 44% of the variability in HRQL. Conclusions: We confirmed many but not all HRQL associations found in smaller studies. A novel observation was that the site of care was an important contributor to HRQL, suggesting that comparison of outcomes and processes among centers may identify best practices.

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalParkinsonism and Related Disorders
Volume20
Issue number3
DOIs
StatePublished - Jan 1 2014

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Parkinson Disease
Quality of Life
Risk Adjustment
Practice Guidelines
Antidepressive Agents
Comorbidity
Linear Models
Patient Care
Cross-Sectional Studies
Observation
Demography
propylene diquat

Keywords

  • Best practices
  • Health related quality of life
  • Parkinson's disease
  • Quality improvement

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Nutt, J. G., Siderowf, A. D., Guttman, M., Schmidt, P. N., Zamudio, J. I., Wu, S. S., ... Nelson, E. C. (2014). Mobility, mood and site of care impact health related quality of life in Parkinson's disease. Parkinsonism and Related Disorders, 20(3), 274-279. https://doi.org/10.1016/j.parkreldis.2013.10.004

Mobility, mood and site of care impact health related quality of life in Parkinson's disease. / Nutt, J. G.; Siderowf, A. D.; Guttman, M.; Schmidt, P. N.; Zamudio, J. I.; Wu, S. S.; Okun, M. S.; Simuni, T.; Parashos, S. A.; Dahodwala, N. A.; Davis, T. L.; Giladi, N.; Gurevich, T.; Hauser, R. A.; Jankovic, J.; Lyons, K. E.; Marsh, L.; Miyasaki, J. M.; Morgan, John Christopher; Santiago, A. J.; Tarsy, D.; Mari, Z.; Malaty, I. A.; Nelson, E. C.

In: Parkinsonism and Related Disorders, Vol. 20, No. 3, 01.01.2014, p. 274-279.

Research output: Contribution to journalArticle

Nutt, JG, Siderowf, AD, Guttman, M, Schmidt, PN, Zamudio, JI, Wu, SS, Okun, MS, Simuni, T, Parashos, SA, Dahodwala, NA, Davis, TL, Giladi, N, Gurevich, T, Hauser, RA, Jankovic, J, Lyons, KE, Marsh, L, Miyasaki, JM, Morgan, JC, Santiago, AJ, Tarsy, D, Mari, Z, Malaty, IA & Nelson, EC 2014, 'Mobility, mood and site of care impact health related quality of life in Parkinson's disease', Parkinsonism and Related Disorders, vol. 20, no. 3, pp. 274-279. https://doi.org/10.1016/j.parkreldis.2013.10.004
Nutt, J. G. ; Siderowf, A. D. ; Guttman, M. ; Schmidt, P. N. ; Zamudio, J. I. ; Wu, S. S. ; Okun, M. S. ; Simuni, T. ; Parashos, S. A. ; Dahodwala, N. A. ; Davis, T. L. ; Giladi, N. ; Gurevich, T. ; Hauser, R. A. ; Jankovic, J. ; Lyons, K. E. ; Marsh, L. ; Miyasaki, J. M. ; Morgan, John Christopher ; Santiago, A. J. ; Tarsy, D. ; Mari, Z. ; Malaty, I. A. ; Nelson, E. C. / Mobility, mood and site of care impact health related quality of life in Parkinson's disease. In: Parkinsonism and Related Disorders. 2014 ; Vol. 20, No. 3. pp. 274-279.
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AU - Schmidt, P. N.

AU - Zamudio, J. I.

AU - Wu, S. S.

AU - Okun, M. S.

AU - Simuni, T.

AU - Parashos, S. A.

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AU - Marsh, L.

AU - Miyasaki, J. M.

AU - Morgan, John Christopher

AU - Santiago, A. J.

AU - Tarsy, D.

AU - Mari, Z.

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AU - Nelson, E. C.

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