TY - JOUR
T1 - Model selection for DCE-T1 studies in glioblastoma
AU - Bagher-Ebadian, Hassan
AU - Jain, Rajan
AU - Nejad-Davarani, Siamak P.
AU - Mikkelsen, Tom
AU - Lu, Mei
AU - Jiang, Quan
AU - Scarpace, Lisa
AU - Arbab, Ali S.
AU - Narang, Jayant
AU - Soltanian-Zadeh, Hamid
AU - Paudyal, Ramesh
AU - Ewing, James R.
PY - 2012/7
Y1 - 2012/7
N2 - Dynamic contrast enhanced T1-weighted MRI using the contrast agent gadopentetate dimeglumine (Gd-DTPA) was performed on 10 patients with glioblastoma. Nested models with as many as three parameters were used to estimate plasma volume or plasma volume and forward vascular transfer constant (Ktrans) and the reverse vascular transfer constant (kep). These constituted models 1, 2, and 3, respectively. Model 1 predominated in normal nonleaky brain tissue, showing little or no leakage of contrast agent. Model 3 predominated in regions associated with aggressive portions of the tumor, and model 2 bordered model 3 regions, showing leakage at reduced rates. In the patient sample, vp was about four times that of white matter in the enhancing part of the tumor. Ktrans varied by a factor of 10 between the model 2 (1.9 ↔ 10-3 min-1) and model 3 regions (1.9 ↔ 10-2 min-1). The mean calculated interstitial space (model 3) was 5.5%. In model 3 regions, excellent curve fits were obtained to summarize concentration-time data (mean R2 = 0.99). We conclude that the three parameters of the standard model are sufficient to fit dynamic contrast enhanced T1 data in glioblastoma under the conditions of the experiment.
AB - Dynamic contrast enhanced T1-weighted MRI using the contrast agent gadopentetate dimeglumine (Gd-DTPA) was performed on 10 patients with glioblastoma. Nested models with as many as three parameters were used to estimate plasma volume or plasma volume and forward vascular transfer constant (Ktrans) and the reverse vascular transfer constant (kep). These constituted models 1, 2, and 3, respectively. Model 1 predominated in normal nonleaky brain tissue, showing little or no leakage of contrast agent. Model 3 predominated in regions associated with aggressive portions of the tumor, and model 2 bordered model 3 regions, showing leakage at reduced rates. In the patient sample, vp was about four times that of white matter in the enhancing part of the tumor. Ktrans varied by a factor of 10 between the model 2 (1.9 ↔ 10-3 min-1) and model 3 regions (1.9 ↔ 10-2 min-1). The mean calculated interstitial space (model 3) was 5.5%. In model 3 regions, excellent curve fits were obtained to summarize concentration-time data (mean R2 = 0.99). We conclude that the three parameters of the standard model are sufficient to fit dynamic contrast enhanced T1 data in glioblastoma under the conditions of the experiment.
KW - DCE MRI
KW - Glioma
KW - Indicator pharmacokinetics
KW - Vascular permeability
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U2 - 10.1002/mrm.23211
DO - 10.1002/mrm.23211
M3 - Article
C2 - 22127934
AN - SCOPUS:84862266573
SN - 0740-3194
VL - 68
SP - 241
EP - 251
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 1
ER -