Model selection for DCE-T1 studies in glioblastoma

Hassan Bagher-Ebadian, Rajan Jain, Siamak P. Nejad-Davarani, Tom Mikkelsen, Mei Lu, Quan Jiang, Lisa Scarpace, Ali Syed Arbab, Jayant Narang, Hamid Soltanian-Zadeh, Ramesh Paudyal, James R. Ewing

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Dynamic contrast enhanced T 1-weighted MRI using the contrast agent gadopentetate dimeglumine (Gd-DTPA) was performed on 10 patients with glioblastoma. Nested models with as many as three parameters were used to estimate plasma volume or plasma volume and forward vascular transfer constant (K trans) and the reverse vascular transfer constant (k ep). These constituted models 1, 2, and 3, respectively. Model 1 predominated in normal nonleaky brain tissue, showing little or no leakage of contrast agent. Model 3 predominated in regions associated with aggressive portions of the tumor, and model 2 bordered model 3 regions, showing leakage at reduced rates. In the patient sample, v p was about four times that of white matter in the enhancing part of the tumor. K trans varied by a factor of 10 between the model 2 (1.9 ↔ 10 -3 min -1) and model 3 regions (1.9 ↔ 10 -2 min -1). The mean calculated interstitial space (model 3) was 5.5%. In model 3 regions, excellent curve fits were obtained to summarize concentration-time data (mean R 2 = 0.99). We conclude that the three parameters of the standard model are sufficient to fit dynamic contrast enhanced T 1 data in glioblastoma under the conditions of the experiment.

Original languageEnglish (US)
Pages (from-to)241-251
Number of pages11
JournalMagnetic Resonance in Medicine
Volume68
Issue number1
DOIs
StatePublished - Jul 1 2012

Fingerprint

Gadolinium DTPA
Plasma Volume
Glioblastoma
Contrast Media
Blood Vessels
Space Simulation
Neoplasms
Brain
White Matter

Keywords

  • DCE MRI
  • Glioma
  • Indicator pharmacokinetics
  • Vascular permeability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Bagher-Ebadian, H., Jain, R., Nejad-Davarani, S. P., Mikkelsen, T., Lu, M., Jiang, Q., ... Ewing, J. R. (2012). Model selection for DCE-T1 studies in glioblastoma. Magnetic Resonance in Medicine, 68(1), 241-251. https://doi.org/10.1002/mrm.23211

Model selection for DCE-T1 studies in glioblastoma. / Bagher-Ebadian, Hassan; Jain, Rajan; Nejad-Davarani, Siamak P.; Mikkelsen, Tom; Lu, Mei; Jiang, Quan; Scarpace, Lisa; Arbab, Ali Syed; Narang, Jayant; Soltanian-Zadeh, Hamid; Paudyal, Ramesh; Ewing, James R.

In: Magnetic Resonance in Medicine, Vol. 68, No. 1, 01.07.2012, p. 241-251.

Research output: Contribution to journalArticle

Bagher-Ebadian, H, Jain, R, Nejad-Davarani, SP, Mikkelsen, T, Lu, M, Jiang, Q, Scarpace, L, Arbab, AS, Narang, J, Soltanian-Zadeh, H, Paudyal, R & Ewing, JR 2012, 'Model selection for DCE-T1 studies in glioblastoma', Magnetic Resonance in Medicine, vol. 68, no. 1, pp. 241-251. https://doi.org/10.1002/mrm.23211
Bagher-Ebadian H, Jain R, Nejad-Davarani SP, Mikkelsen T, Lu M, Jiang Q et al. Model selection for DCE-T1 studies in glioblastoma. Magnetic Resonance in Medicine. 2012 Jul 1;68(1):241-251. https://doi.org/10.1002/mrm.23211
Bagher-Ebadian, Hassan ; Jain, Rajan ; Nejad-Davarani, Siamak P. ; Mikkelsen, Tom ; Lu, Mei ; Jiang, Quan ; Scarpace, Lisa ; Arbab, Ali Syed ; Narang, Jayant ; Soltanian-Zadeh, Hamid ; Paudyal, Ramesh ; Ewing, James R. / Model selection for DCE-T1 studies in glioblastoma. In: Magnetic Resonance in Medicine. 2012 ; Vol. 68, No. 1. pp. 241-251.
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