Modeling schizophrenia in neuregulin 1 and ErbB4 mutant mice

Yisheng Lu, Dongmin Yin, Wencheng Xiong, Lin Mei

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Schizophrenia, a most prevalent brain disorder, remains to be one of the least understood. Unlike Alzheimer's disease or Parkinson's disease, schizophrenia lacks clear pathological lesions, which has made it difficult to model in animals. However, genetic studies have recently identified many susceptibility genes of this disorder including neuregulin 1 (NRG1) and its receptor ErbB4. Arguably, relevant mutant mice have provided a unique opportunity to model "schizophrenia" in animals where expression or function of susceptibility genes is altered. This review summarizes recent studies of NRG1 and ErbB4 mutant mice and their implication in schizophrenic pathology.

Original languageEnglish (US)
Title of host publicationAnimal Models of Schizophrenia and Related Disorders
EditorsPatrick O'Donnell
Pages261-277
Number of pages17
DOIs
StatePublished - Jul 1 2011

Publication series

NameNeuromethods
Volume59
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • ErbB4
  • Neuregulin 1
  • hyperactivity
  • mouse model
  • neurotransmission
  • prepulse inhibition
  • psychiatric disorders
  • rodents
  • schizophrenia
  • synaptic plasticity
  • working memory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Psychiatry and Mental health

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  • Cite this

    Lu, Y., Yin, D., Xiong, W., & Mei, L. (2011). Modeling schizophrenia in neuregulin 1 and ErbB4 mutant mice. In P. O'Donnell (Ed.), Animal Models of Schizophrenia and Related Disorders (pp. 261-277). (Neuromethods; Vol. 59). https://doi.org/10.1007/978-1-61779-157-4_12