Models for Central Nervous System Complications of Antiphospholipid Syndrome

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

One of the clinical hallmarks of antiphospholipid syndrome is the development of neurological complications, namely cerebral ischaemia, chorea, multi-infarct dementia, amaurosis fugax, migraine and transverse myelitis. An animal model should include the development of measurable neurological deficits and evidence of cerebral infarction. Although there are a number of mouse models for fetal loss, there has been no convincing model for the neurological complications of the antiphosphohpid syndrome. One explanation for the high frequency of neurological events in antiphospholipid syndrome is a vulnerability of the cerebral vasculature to the hypercoagulable state associated with the syndrome. A greater appreciation of the differences in the regulation of coagulation between the systemic and cerebral vasculatures may be key to understanding the apparent predilection for central nervous system involvement in the antiphospholipid syndrome.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalLupus
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1994

Fingerprint

Antiphospholipid Syndrome
Central Nervous System
Neurological Models
Amaurosis Fugax
Multi-Infarct Dementia
Transverse Myelitis
Chorea
Cerebral Infarction
Brain Ischemia
Migraine Disorders
Animal Models

Keywords

  • Animal model
  • Antiphospholipid
  • Cerebral infarction
  • Endothelial

ASJC Scopus subject areas

  • Rheumatology

Cite this

Models for Central Nervous System Complications of Antiphospholipid Syndrome. / Hess, David C.

In: Lupus, Vol. 3, No. 4, 01.01.1994, p. 253-257.

Research output: Contribution to journalArticle

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