Modification of GABAA receptor function by an analog of cyclic AMP

Neil L. Harrison, Nevin A. Lambert

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Chloride-dependent current responses to γ-aminobutyric acid (GABA) were recorded from cultured rat hippocampal neurons under voltage clamp. In the presence of the membrane-permeable cyclic AMP analog, 8-bromo-cyclic AMP (8-Br-cAMP), the peak current response to GABA was reduced, although the reversal potential for the current evoked by GABA was unaltered; similar concentrations of 8-bromo-cyclic GMP did not alter the GABA response. 8-Br-cAMP also increased spontaneous activity of the neurons and blocked accommodation of firing. It is possible that the alterations in responses to GABA result from the activation of cyclic AMP-dependent protein kinase (cAMP-PK) and subsequent phosphorylation of the GABAA receptor.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalNeuroscience Letters
Volume105
Issue number1-2
DOIs
StatePublished - Oct 23 1989
Externally publishedYes

Keywords

  • 8-Bromo-cyclic AMP
  • 8-Bromo-cyclic GMP
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)

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