Modification of morphine antinociceptive response by blood glucose status: Possible involvement of cellular energetics

Ishwar S. Singh, Tapan K. Chatterjee, Jagat J. Ghosh

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The antinociceptive response to morphine was enhanced in insulin-hypoglycemic animals whereas it was decreased in diabetic or in hypertonic glucose-pretreated hyperglycemic animals. 3-O-Methylglucose was, however, without effect on morphine analgesia whereas 2-deoxyglucose sensitized this effect. Furthermore, as malate and isocitrate attenuated the morphine analgesic response of insulin hypoglycemic animals and 2,4-dinitrophenol sensitized this response in diabetic animals, it is possible that the blood glucose level affects the morphine analgesic response by affecting cellular energetics.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalEuropean Journal of Pharmacology
Volume90
Issue number4
DOIs
StatePublished - Jun 17 1983

Keywords

  • Blood glucose
  • Cellular energetics
  • Morphine analgesia

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Modification of morphine antinociceptive response by blood glucose status: Possible involvement of cellular energetics'. Together they form a unique fingerprint.

  • Cite this