Modification of morphine antinociceptive response by blood glucose status

Possible involvement of cellular energetics

Ishwar S. Singh, Tapan K. Chatterjee, Jagat J. Ghosh

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The antinociceptive response to morphine was enhanced in insulin-hypoglycemic animals whereas it was decreased in diabetic or in hypertonic glucose-pretreated hyperglycemic animals. 3-O-Methylglucose was, however, without effect on morphine analgesia whereas 2-deoxyglucose sensitized this effect. Furthermore, as malate and isocitrate attenuated the morphine analgesic response of insulin hypoglycemic animals and 2,4-dinitrophenol sensitized this response in diabetic animals, it is possible that the blood glucose level affects the morphine analgesic response by affecting cellular energetics.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalEuropean Journal of Pharmacology
Volume90
Issue number4
DOIs
StatePublished - Jun 17 1983

Fingerprint

Morphine
Blood Glucose
Hypoglycemic Agents
Analgesics
3-O-Methylglucose
Insulin
2,4-Dinitrophenol
Deoxyglucose
Analgesia
Glucose

Keywords

  • Blood glucose
  • Cellular energetics
  • Morphine analgesia

ASJC Scopus subject areas

  • Pharmacology

Cite this

Modification of morphine antinociceptive response by blood glucose status : Possible involvement of cellular energetics. / Singh, Ishwar S.; Chatterjee, Tapan K.; Ghosh, Jagat J.

In: European Journal of Pharmacology, Vol. 90, No. 4, 17.06.1983, p. 437-439.

Research output: Contribution to journalArticle

Singh, Ishwar S. ; Chatterjee, Tapan K. ; Ghosh, Jagat J. / Modification of morphine antinociceptive response by blood glucose status : Possible involvement of cellular energetics. In: European Journal of Pharmacology. 1983 ; Vol. 90, No. 4. pp. 437-439.
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