Modulation of cranial bone healing with a heparin-like dextran derivative

Daniel Albo, Charles Long, Nirag Jhala, Barbara Atkinson, Mark S. Granick, Thomas Wang, Anne Meddahi, Denis Barritault, Mark P. Solomon

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Substituted dextran polymers have been shown to bind growth factors and protect them from enzymatic degradation. Using this information, other researchers have been able to use these substituted dextrans to enhance the healing of bone in an environment where bone would otherwise not regenerate. We used substituted dextran polymers to evaluate their ability to accelerate the healing of cranial bone in a rabbit model. We were able to document a more rapid rate of healing and demonstrate micrographic evidence to support that conclusion. Possible mechanisms are postulated.

Original languageEnglish (US)
Pages (from-to)19-22
Number of pages4
JournalJournal of Craniofacial Surgery
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • Bone healing
  • Cranial bone
  • Enzyme degradation
  • Growth factor binding
  • Rabbit
  • Substituted dextran polymer

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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  • Cite this

    Albo, D., Long, C., Jhala, N., Atkinson, B., Granick, M. S., Wang, T., Meddahi, A., Barritault, D., & Solomon, M. P. (1996). Modulation of cranial bone healing with a heparin-like dextran derivative. Journal of Craniofacial Surgery, 7(1), 19-22. https://doi.org/10.1097/00001665-199601000-00007