Modulation of inflammatory responses by Wnt/β-catenin signaling in dendritic cells: A novel immunotherapy target for autoimmunity and cancer

Amol Suryawanshi, Raghu K. Tadagavadi, Daniel Swafford, Santhakumar Manicassamy

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway critical for several biological processes. An aberrant Wnt/β-catenin signaling is linked to several human diseases. Emerging studies have highlighted the regulatory role of the Wnt/β-catenin signaling pathway in normal physiological processes of parenchymal and hematopoietic cells. Recent studies have shown that the activation of Wnt/β-catenin pathway in dendritic cells (DCs) play a critical role in mucosal tolerance and suppression of chronic autoimmune pathologies. Alternatively, tumors activate Wnt/β-catenin pathway in DCs to induce immune tolerance and thereby evade antitumor immunity through suppression of effector T cell responses and promotion of regulatory T cell responses. Here, we review our work and current understanding of how Wnt/β-catenin signaling in DCs shapes the immune response in cancer and autoimmunity and discuss how Wnt/β-catenin pathway can be targeted for successful therapeutic interventions in various human diseases.

Original languageEnglish (US)
Article number460
JournalFrontiers in immunology
Volume7
Issue numberOCT
DOIs
StatePublished - Oct 27 2016

Keywords

  • Autoimmune diseases, antitumor immunity
  • Dendritic cells
  • Immune-tolerance
  • Immuno-oncology
  • Immunotherapy
  • Wnt
  • β-catenin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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