Modulation of late phases of long-term potentiation in rat dentate gyrus by stimulation of the medial septum

Sabine Martina Frey, J. A. Bergado, Julietta Uta Frey

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The prolonged maintenance of hippocampal long-term potentiation (LTP) seems to require heterosynaptic events during its induction. We have previously shown that stimulation of the basolateral nucleus of the amygdala (BLA) within a distinct time window can reinforce a transient early-LTP into a long-lasting late-LTP in the dentate gyrus (DG) in freely moving rats. We have shown that this reinforcement was dependent on β-adrenergic and/or muscarinergic receptor activation and protein synthesis. However, since the BLA does not directly stimulate the DG the question remained by which inputs such heterosynaptic processes are triggered. We have now directly stimulated the medial septal pathway 15 min after induction of early-LTP in the DG and show that this input is capable of reinforcing early into late-LTP in a frequency-dependent manner. This septal reinforcement of DG LTP was dependent on β-adrenergic receptor activation and protein synthesis. We suggest that the reinforcing effect of the BLA stimulation can, potentially, be mediated via the septal input to the DG, though it differs in its ability to induce or modulate functional plasticity.

Original languageEnglish (US)
Pages (from-to)1055-1062
Number of pages8
JournalNeuroscience
Volume118
Issue number4
DOIs
StatePublished - Jun 6 2003

Fingerprint

Long-Term Potentiation
Dentate Gyrus
Amygdala
Adrenergic Agents
Adrenergic Receptors
Proteins
Basolateral Nuclear Complex

Keywords

  • Hippocampus
  • Late-LTP
  • Learning
  • Memory formation
  • Reinforcement
  • Septum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Modulation of late phases of long-term potentiation in rat dentate gyrus by stimulation of the medial septum. / Frey, Sabine Martina; Bergado, J. A.; Frey, Julietta Uta.

In: Neuroscience, Vol. 118, No. 4, 06.06.2003, p. 1055-1062.

Research output: Contribution to journalArticle

Frey, Sabine Martina ; Bergado, J. A. ; Frey, Julietta Uta. / Modulation of late phases of long-term potentiation in rat dentate gyrus by stimulation of the medial septum. In: Neuroscience. 2003 ; Vol. 118, No. 4. pp. 1055-1062.
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