Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide

Paul M. O'Connor, Allen W. Cowley

Research output: Contribution to journalReview article

38 Scopus citations


The renal pressure-natriuresis mechanism is the dominant controller of body fluid balance and long-term arterial pressure. In recent years, it has become clear that the balance of reactive oxygen and nitrogen species within the renal medullary region is a key determinant of the set point of the renal pressure-natriuresis curve. The development of renal medullary oxidative stress causes dysfunction of the pressure-natriuresis mechanism and contributes to the development of hypertension in numerous disease models. The purpose of this review is to point out the known mechanisms within the renal medulla through which reactive oxygen and nitrogen species modulate the pressure-natriuresis response and to update the reader on recent advances in this field.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalCurrent Hypertension Reports
Issue number2
Publication statusPublished - Apr 1 2010
Externally publishedYes



  • Diuresis
  • Hydrogen-peroxide
  • Kidney
  • Medulla
  • Salt-sensitivity
  • Superoxide

ASJC Scopus subject areas

  • Internal Medicine

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