Molecular characterization of a (1;10)(p22;q21) constitutional translocation from a patient with neuroblastoma

R. Scott Mead, John Kenneth Cowell

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A constitutional t(1;10)(p22;q21) from a patient with stage IVS neuroblastoma has been isolated in somatic cell hybrids and the position of the breakpoints analyzed. On chromosome 1 the breakpoint lies in a 4-Mbp region flanked by minisatellite marker D1S234 and by D1S188, which lies in the region of F3. The chromosome 10 breakpoint lies between RBP3 and NAKNR below the MEN2 locus. Because, in patients with genetic disease, constitutional translocations frequently interrupt genes which are related to the clinical phenotype this rearrangement has identified two regions which potentially contain genes related to the development of neuroblastoma.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume81
Issue number2
DOIs
StatePublished - Jan 1 1995

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Chromosome Breakpoints
Neuroblastoma
Chromosomes, Human, Pair 10
Minisatellite Repeats
Inborn Genetic Diseases
Hybrid Cells
Chromosomes, Human, Pair 1
Genes
Phenotype

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Molecular characterization of a (1;10)(p22;q21) constitutional translocation from a patient with neuroblastoma. / Scott Mead, R.; Cowell, John Kenneth.

In: Cancer Genetics and Cytogenetics, Vol. 81, No. 2, 01.01.1995, p. 151-157.

Research output: Contribution to journalArticle

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