Molecular genetic analysis of the duplication of human inducible nitric oxide synthase (NOS2) sequences

Wei Ming Xu, Ian G. Charles, Liz Hi Liu, Pandelakis Koni, Salvador Moncada, Piers Emson

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In previous studies, we found multiple copies of inducible nitric oxide synthase gene (NOS2)-like sequences in the human genome and mapped them to the pericentric region of chromosome 17. Here, we describe the cloning and sequencing of exon22 regions from three of these NOS2-like sequences. We have also mapped another NOS2-like sequence to human chromosome 14. Since there are multiple NOS2-like sequences present in the human genome, we have also carried out Zoo Blot hybridisation analysis using a NOS2 cDNA probe. Our data suggest that duplication of NOS2-like sequences occurred very recently in primate evolution.

Original languageEnglish (US)
Pages (from-to)466-472
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume212
Issue number2
DOIs
StatePublished - Jul 17 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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