Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease

N. Latov; A. P. Hays; P. D. Donofrio; J. Liao; H. Ito; S. McGinnis; K. Manoussos; L. Freddo; M. E. Shy; W. H. Sherman; H. W. Chang; H. S. Greenberg; J. W. Albers; A. G. Alessi; D. Keren; R. K. Yu; L. P. Rowland; E. A. Kabat

doi:10.1212/wnl.38.5.763

Monoclonal IgM with unique specificity to gangliosides GM₁ and GD_1b and to lacto-N-tetraose associated with human motor neuron disease

N. Latov, A. P. Hays, P. D. Donofrio, J. Liao, H. Ito, S. McGinnis, K. Manoussos, L. Freddo, M. E. Shy, W. H. Sherman, H. W. Chang, H. S. Greenberg, J. W. Albers, A. G. Alessi, D. Keren, R. K. Yu, L. P. Rowland, E. A. Kabat

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM₁ and GD_1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.

Original language	English (US)
Pages (from-to)	763-768
Number of pages	6
Journal	Neurology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1212/wnl.38.5.763
State	Published - May 1988
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.38.5.763

Cite this

Latov, N., Hays, A. P., Donofrio, P. D., Liao, J., Ito, H., McGinnis, S., Manoussos, K., Freddo, L., Shy, M. E., Sherman, W. H., Chang, H. W., Greenberg, H. S., Albers, J. W., Alessi, A. G., Keren, D., Yu, R. K., Rowland, L. P., & Kabat, E. A. (1988). Monoclonal IgM with unique specificity to gangliosides GM₁ and GD_1b and to lacto-N-tetraose associated with human motor neuron disease. Neurology, 38(5), 763-768. https://doi.org/10.1212/wnl.38.5.763

Latov, N, Hays, AP, Donofrio, PD, Liao, J, Ito, H, McGinnis, S, Manoussos, K, Freddo, L, Shy, ME, Sherman, WH, Chang, HW, Greenberg, HS, Albers, JW, Alessi, AG, Keren, D, Yu, RK, Rowland, LP & Kabat, EA 1988, 'Monoclonal IgM with unique specificity to gangliosides GM₁ and GD_1b and to lacto-N-tetraose associated with human motor neuron disease', Neurology, vol. 38, no. 5, pp. 763-768. https://doi.org/10.1212/wnl.38.5.763

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abstract = "IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM1 and GD1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.",

author = "N. Latov and Hays, {A. P.} and Donofrio, {P. D.} and J. Liao and H. Ito and S. McGinnis and K. Manoussos and L. Freddo and Shy, {M. E.} and Sherman, {W. H.} and Chang, {H. W.} and Greenberg, {H. S.} and Albers, {J. W.} and Alessi, {A. G.} and D. Keren and Yu, {R. K.} and Rowland, {L. P.} and Kabat, {E. A.}",

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AU - Latov, N.

AU - Hays, A. P.

AU - Donofrio, P. D.

AU - Liao, J.

AU - Ito, H.

AU - McGinnis, S.

AU - Manoussos, K.

AU - Freddo, L.

AU - Shy, M. E.

AU - Sherman, W. H.

AU - Chang, H. W.

AU - Greenberg, H. S.

AU - Albers, J. W.

AU - Alessi, A. G.

AU - Keren, D.

AU - Yu, R. K.

AU - Rowland, L. P.

AU - Kabat, E. A.

PY - 1988/5

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