Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease

N. Latov, A. P. Hays, P. D. Donofrio, J. Liao, H. Ito, S. McGinnis, K. Manoussos, L. Freddo, M. E. Shy, W. H. Sherman, H. W. Chang, H. S. Greenberg, J. W. Albers, A. G. Alessi, D. Keren, Robert K Yu, L. P. Rowland, E. A. Kabat

Research output: Contribution to journalArticle

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Abstract

IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM1 and GD1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.

Original languageEnglish (US)
Pages (from-to)763-768
Number of pages6
JournalNeurology
Volume38
Issue number5
StatePublished - Jan 1 1988

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G(M1) Ganglioside
Motor Neuron Disease
Immunoglobulin M
Motor Endplate
Nerve Tissue
Paraproteinemias
Antibody Specificity
Neuromuscular Junction
Peripheral Nerves
Fluorescence Microscopy
Epitopes
Monoclonal Antibodies
Serum
lacto-N-neotetraose

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Latov, N., Hays, A. P., Donofrio, P. D., Liao, J., Ito, H., McGinnis, S., ... Kabat, E. A. (1988). Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease. Neurology, 38(5), 763-768.

Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease. / Latov, N.; Hays, A. P.; Donofrio, P. D.; Liao, J.; Ito, H.; McGinnis, S.; Manoussos, K.; Freddo, L.; Shy, M. E.; Sherman, W. H.; Chang, H. W.; Greenberg, H. S.; Albers, J. W.; Alessi, A. G.; Keren, D.; Yu, Robert K; Rowland, L. P.; Kabat, E. A.

In: Neurology, Vol. 38, No. 5, 01.01.1988, p. 763-768.

Research output: Contribution to journalArticle

Latov, N, Hays, AP, Donofrio, PD, Liao, J, Ito, H, McGinnis, S, Manoussos, K, Freddo, L, Shy, ME, Sherman, WH, Chang, HW, Greenberg, HS, Albers, JW, Alessi, AG, Keren, D, Yu, RK, Rowland, LP & Kabat, EA 1988, 'Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease', Neurology, vol. 38, no. 5, pp. 763-768.
Latov, N. ; Hays, A. P. ; Donofrio, P. D. ; Liao, J. ; Ito, H. ; McGinnis, S. ; Manoussos, K. ; Freddo, L. ; Shy, M. E. ; Sherman, W. H. ; Chang, H. W. ; Greenberg, H. S. ; Albers, J. W. ; Alessi, A. G. ; Keren, D. ; Yu, Robert K ; Rowland, L. P. ; Kabat, E. A. / Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease. In: Neurology. 1988 ; Vol. 38, No. 5. pp. 763-768.
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AU - Hays, A. P.

AU - Donofrio, P. D.

AU - Liao, J.

AU - Ito, H.

AU - McGinnis, S.

AU - Manoussos, K.

AU - Freddo, L.

AU - Shy, M. E.

AU - Sherman, W. H.

AU - Chang, H. W.

AU - Greenberg, H. S.

AU - Albers, J. W.

AU - Alessi, A. G.

AU - Keren, D.

AU - Yu, Robert K

AU - Rowland, L. P.

AU - Kabat, E. A.

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N2 - IgM lambda monoclonal antibodies in two patients with motor neuron disease showed the same unique antigenic specificity. They bound to gangliosides GM1 and GD1b and to lacto-N-tetraose-BSA. By immunofluorescence microscopy they bound to central and peripheral nerve tissue and to motor end-plates at the neuromuscular junction. Sera from control subjects did not contain antibodies of similar specificity. Monoclonal IgMs with the same unique specificity could be responsible for motor neuron disease in some patients with monoclonal gammopathies.

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