Monomorphous angiocentric glioma: A distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma

Min Wang, Tarik Tihan, Amyn Mohammed Rojiani, Surender R. Bodhireddy, Richard A. Prayson, John J. Iacuone, Ajit J. Alles, David J. Donahue, Richard B. Hessler, Jung H. Kim, Mark Haas, Marc K. Rosenblum, Peter C. Burger

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

We present 8 examples of a neoplasm with features of both astrocytoma and ependymoma that may represent a distinct clinicopathologic entity. The cerebral hemispheric tumors occurred in patients that were 3, 4, 12, 14, 15, 26, 30, and 37 years of age. All presented with seizures that, with the exception of 2, began in childhood. Magnetic resonance imaging studies showed ill-defined, T2-hyperintense, generally noncontrast-enhancing lesions that, although centered on the cortex or amygdala, extended into the underlying white matter for a short distance. Histologically, the variably infiltrative tumors were distinctively angiocentric with well-developed perivascular pseudorosettes in some cases. Longitudinal and/or circumferential orientations of perivascular cells were common also. The cells were uniform in their cytologic features from case to case and were bipolar in all but one case. A glial nature was inferred from immunoreactivity for GFAP, and ependymal differentiation was suggested by positivity for EMA in three cases and ultrastructural features in one. Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal.

Original languageEnglish (US)
Pages (from-to)875-881
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume64
Issue number10
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Ependymoma
Astrocytoma
Glioma
Neoplasms
Amygdala
Neuroglia
Seizures
Magnetic Resonance Imaging

Keywords

  • Angiocentric
  • Astrocytoma
  • Bipolar
  • Ependymoma
  • Epilepsy
  • Glioma
  • Pediatric

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Monomorphous angiocentric glioma : A distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. / Wang, Min; Tihan, Tarik; Rojiani, Amyn Mohammed; Bodhireddy, Surender R.; Prayson, Richard A.; Iacuone, John J.; Alles, Ajit J.; Donahue, David J.; Hessler, Richard B.; Kim, Jung H.; Haas, Mark; Rosenblum, Marc K.; Burger, Peter C.

In: Journal of Neuropathology and Experimental Neurology, Vol. 64, No. 10, 10.2005, p. 875-881.

Research output: Contribution to journalArticle

Wang, M, Tihan, T, Rojiani, AM, Bodhireddy, SR, Prayson, RA, Iacuone, JJ, Alles, AJ, Donahue, DJ, Hessler, RB, Kim, JH, Haas, M, Rosenblum, MK & Burger, PC 2005, 'Monomorphous angiocentric glioma: A distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma', Journal of Neuropathology and Experimental Neurology, vol. 64, no. 10, pp. 875-881. https://doi.org/10.1097/01.jnen.0000182981.02355.10
Wang, Min ; Tihan, Tarik ; Rojiani, Amyn Mohammed ; Bodhireddy, Surender R. ; Prayson, Richard A. ; Iacuone, John J. ; Alles, Ajit J. ; Donahue, David J. ; Hessler, Richard B. ; Kim, Jung H. ; Haas, Mark ; Rosenblum, Marc K. ; Burger, Peter C. / Monomorphous angiocentric glioma : A distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. In: Journal of Neuropathology and Experimental Neurology. 2005 ; Vol. 64, No. 10. pp. 875-881.
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