Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy

Justin M.M. Cates, Jennifer Black, Carmen C. Wolfe, Eric T. Shinohara, Ginger E. Holt, Vicki L. Keedy, Kenneth R. Hande, Kelly Cornett Homlar, Jennifer L. Halpern, Herbert S. Schwartz, Ashley Troutman, Cheryl M. Coffin

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6 Citations (Scopus)

Abstract

The morphologic changes seen in desmoid-type fibromatosis after radiotherapy have not been well studied, and the degree of cytologic atypia, cellularity, mitotic activity, and lesional necrosis found in desmoid-type fibromatosis treated with ionizing radiation has not been thoroughly assessed. Therefore, we evaluated a series of primary and locally recurrent desmoid-type fibromatoses resected at variable intervals after radiation therapy (XRT) and compared their histopathologic and immunophenotypic features with paired pathologic specimens that were obtained before radiotherapy. The morphologic characteristics of desmoid-type fibromatoses resected before and after radiotherapy were not significantly different in 7 of the 8 cases studied. One case resected 191 months after XRT showed morphologic evidence of fibrosarcomatous transformation, with zonal necrosis, hypercellularity, severe nuclear atypia, and increased mitotic activity. No significant differences in the immunophenotype of desmoid-type fibromatosis were observed after XRT. In rare cases of recurrent desmoid-type fibromatosis, the differential diagnosis may include radiation-induced fibrosarcoma. Our data suggest that histomorphologic alterations attributable to the effects of ionizing radiation in desmoid-type fibromatosis are minimal. Therefore, the presence of cytologic features of malignancy in this setting warrants careful examination and consideration of the rare occurrence of postradiation sarcoma. Lesser degrees of nuclear atypia seen in isolation do not necessarily indicate a poor prognosis in irradiated desmoid-type fibromatosis.

Original languageEnglish (US)
Pages (from-to)1418-1424
Number of pages7
JournalHuman Pathology
Volume43
Issue number9
DOIs
StatePublished - Sep 1 2012

Fingerprint

Aggressive Fibromatosis
Fibroma
Radiotherapy
Ionizing Radiation
Necrosis
Fibrosarcoma
Sarcoma
Differential Diagnosis
Radiation

Keywords

  • Desmoid-type fibromatosis
  • Postradiation sarcoma
  • Radiation effect

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cates, J. M. M., Black, J., Wolfe, C. C., Shinohara, E. T., Holt, G. E., Keedy, V. L., ... Coffin, C. M. (2012). Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy. Human Pathology, 43(9), 1418-1424. https://doi.org/10.1016/j.humpath.2011.11.002

Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy. / Cates, Justin M.M.; Black, Jennifer; Wolfe, Carmen C.; Shinohara, Eric T.; Holt, Ginger E.; Keedy, Vicki L.; Hande, Kenneth R.; Homlar, Kelly Cornett; Halpern, Jennifer L.; Schwartz, Herbert S.; Troutman, Ashley; Coffin, Cheryl M.

In: Human Pathology, Vol. 43, No. 9, 01.09.2012, p. 1418-1424.

Research output: Contribution to journalArticle

Cates, JMM, Black, J, Wolfe, CC, Shinohara, ET, Holt, GE, Keedy, VL, Hande, KR, Homlar, KC, Halpern, JL, Schwartz, HS, Troutman, A & Coffin, CM 2012, 'Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy', Human Pathology, vol. 43, no. 9, pp. 1418-1424. https://doi.org/10.1016/j.humpath.2011.11.002
Cates, Justin M.M. ; Black, Jennifer ; Wolfe, Carmen C. ; Shinohara, Eric T. ; Holt, Ginger E. ; Keedy, Vicki L. ; Hande, Kenneth R. ; Homlar, Kelly Cornett ; Halpern, Jennifer L. ; Schwartz, Herbert S. ; Troutman, Ashley ; Coffin, Cheryl M. / Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy. In: Human Pathology. 2012 ; Vol. 43, No. 9. pp. 1418-1424.
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