Morphometric analysis of the developing optic nerve of the F1 heterotic mouse and its parental strains

John W. Bigbee, David S. Yu, Robert K Yu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

During the period of active myelination, the CNS of the F1 hybrid mouse, derived from DBA/2J (D2) and C57BL/6J (B6) parental strains, displays levels of myelin-specific markers which are greater than in either parent. This so-called hypermyelination has been attributed to hybrid vigor or heterosis. Morphometric comparison of the optic nerves of F1 and parental strains revealed that the F1 contains larger myelinated axons and fewer premyelinated axons. These observations suggest that, compared with its parental strains, the F1 hybrid shows an early onset and accelerated rate of myelination.

Original languageEnglish (US)
Pages (from-to)179-181
Number of pages3
JournalNeuroscience Letters
Volume119
Issue number2
DOIs
StatePublished - Nov 13 1990
Externally publishedYes

Keywords

  • Development
  • Electron microscopy
  • Heterosis
  • Mouse strain
  • Myelination
  • Optic nerve

ASJC Scopus subject areas

  • Neuroscience(all)

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