Abstract
During the period of active myelination, the CNS of the F1 hybrid mouse, derived from DBA/2J (D2) and C57BL/6J (B6) parental strains, displays levels of myelin-specific markers which are greater than in either parent. This so-called hypermyelination has been attributed to hybrid vigor or heterosis. Morphometric comparison of the optic nerves of F1 and parental strains revealed that the F1 contains larger myelinated axons and fewer premyelinated axons. These observations suggest that, compared with its parental strains, the F1 hybrid shows an early onset and accelerated rate of myelination.
Original language | English (US) |
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Pages (from-to) | 179-181 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 119 |
Issue number | 2 |
DOIs | |
State | Published - Nov 13 1990 |
Externally published | Yes |
Keywords
- Development
- Electron microscopy
- Heterosis
- Mouse strain
- Myelination
- Optic nerve
ASJC Scopus subject areas
- General Neuroscience